Dopamine multilocus genetic profile, spontaneous activity of left superior temporal gyrus, and early therapeutic effect in major depressive disorder
X Liu, Z Hou, Y Yin, C Xie, H Zhang, H Zhang… - Frontiers in …, 2020 - frontiersin.org
Objectives: This study aimed to examine the interactive effects of dopamine (DA) pathway
gene and disease on spontaneous brain activity and further to explore the relationship …
gene and disease on spontaneous brain activity and further to explore the relationship …
Mediating role of the reward network in the relationship between the dopamine multilocus genetic profile and depression
L Gong, C He, Y Yin, H Wang, Q Ye, F Bai… - Frontiers in Molecular …, 2017 - frontiersin.org
Multiple genetic loci in the dopamine (DA) pathway have been associated with depression
symptoms in patients with major depressive disorder (MDD). However, the neural …
symptoms in patients with major depressive disorder (MDD). However, the neural …
Increased temporal variability of striatum region facilitating the early antidepressant response in patients with major depressive disorder
The aim of this study is to identify the difference of temporal variability among major
depressive disorder (MDD) patients (with different early antidepressant responses) and …
depressive disorder (MDD) patients (with different early antidepressant responses) and …
An investigation into the association between dopamine receptor D1 multilocus genetic variation, multiparametric magnetic resonance imaging, and antidepressant …
Y Sun, X Wang, S Tian, Z Chen, H Wang… - Journal of Magnetic …, 2022 - Wiley Online Library
Background Combining genetic variants with neuroimaging phenotypes may facilitate
understanding of the biological mechanisms for the etiology and pharmacology of …
understanding of the biological mechanisms for the etiology and pharmacology of …
The association between DRD3 Ser9Gly polymorphism and depression severity in Parkinson's disease
Y Zhi, Y Yuan, Q Si, M Wang, Y Shen… - Parkinson's …, 2019 - Wiley Online Library
More and more evidence suggests that dopamine receptor D3 gene (DRD3) plays an
important role in the clinical manifestations and the treatment of Parkinson's disease (PD) …
important role in the clinical manifestations and the treatment of Parkinson's disease (PD) …
[HTML][HTML] Common and unique neural activities in subclinical depression and major depressive disorder indicate the development of brain impairments in different …
B Zhang, S Liu, S Chen, F Yan, Y Ke, L Chen… - Journal of Affective …, 2022 - Elsevier
Background Subclinical depression (SD) and major depressive disorder (MDD) can be
considered as the early and late stages of depression, but the characteristics of intrinsic …
considered as the early and late stages of depression, but the characteristics of intrinsic …
Links among genetic variants and hierarchical brain structural and functional networks for antidepressant treatment: A multivariate study
Y Sun, Y Hou, X Wang, H Wang, R Yan, L Xue, Z Yao… - Brain Research, 2024 - Elsevier
Background Antidepressant treatment effects are strongly heritable and have substantial
effects on brain function and structure, but the underlying mechanisms are still poorly …
effects on brain function and structure, but the underlying mechanisms are still poorly …
Serotonin 2A receptor polymorphism rs3803189 mediated by dynamics of default mode network: a potential biomarker for antidepressant early response
Y Sun, S Tao, S Tian, J Shao, Z Mo, X Wang… - Journal of Affective …, 2021 - Elsevier
Abstract Background: Serotonin 2A receptors (HTR2A) play a crucial role in the therapeutic
response to antidepressant. The activity of serotonergic system could modulate the …
response to antidepressant. The activity of serotonergic system could modulate the …
Resting-state brain activation correlates with short-time antidepressant treatment outcome in drug-naive patients with major depressive disorder
LJ Wang, WH Kuang, JJ Xu, D Lei… - Journal of international …, 2014 - journals.sagepub.com
Objective A resting-state functional magnetic resonance imaging study (fMRI) to investigate
pretreatment regional differences in brain function, in patients with early treatment …
pretreatment regional differences in brain function, in patients with early treatment …
Local dynamic spontaneous brain activity changes in first-episode, treatment-naive patients with major depressive disorder and their associated gene expression …
K Xue, S Liang, B Yang, D Zhu, Y Xie, W Qin… - Psychological …, 2022 - cambridge.org
BackgroundMajor depressive disorder (MDD) is a common debilitating disorder
characterized by impaired spontaneous brain activity, yet little is known about its alterations …
characterized by impaired spontaneous brain activity, yet little is known about its alterations …