[HTML][HTML] The enzymatic biosynthesis of acylated steroidal glycosides and their cytotoxic activity
M Liu, JQ Kong - Acta pharmaceutica sinica B, 2018 - Elsevier
Herein we describe the discovery and functional characterization of a steroidal
glycosyltransferase (SGT) from Ornithogalum saundersiae and a steroidal glycoside …
glycosyltransferase (SGT) from Ornithogalum saundersiae and a steroidal glycoside …
An enzymatic approach to configurationally rare trans‐androsteronyl‐α‐glucoside and Its potential anticancer application
FP Chou, CT Tsai, YS Chiou, YJ Chen… - Chemical Biology & …, 2017 - Wiley Online Library
Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP 0421 shows protein
plasticity on generation of configurationally rare steryl‐α‐glucosides. Investigation of trans …
plasticity on generation of configurationally rare steryl‐α‐glucosides. Investigation of trans …
UGT74AN1, a Permissive Glycosyltransferase from Asclepias curassavica for the Regiospecific Steroid 3-O-Glycosylation
C Wen, W Huang, XL Zhu, XS Li, F Zhang… - Organic letters, 2018 - ACS Publications
A permissive steroid glycosyltransferase (UGT74AN1) from Asclepias curassavica exhibited
robust capabilities for the regiospecific C3 glycosylation of cardiotonic steroids and C21 …
robust capabilities for the regiospecific C3 glycosylation of cardiotonic steroids and C21 …
OcUGT1-catalyzed glycosylation of testosterone with alternative donor substrates
S Yuan, S Yin, M Liu, JM He, JQ Kong - Process biochemistry, 2018 - Elsevier
Abstract Testosterone 17-O-glucoside (T-17-G) is a precursor of the anticancer compound
3′-acetylated testosterone 17-O-β-glucoside (3′-AT-G). The biosynthesis of T-17-G was …
3′-acetylated testosterone 17-O-β-glucoside (3′-AT-G). The biosynthesis of T-17-G was …
[HTML][HTML] OcUGT1-catalyzing glycodiversification of steroids through glucosylation and transglucosylation actions
YL Xu, JQ Kong - Molecules, 2020 - mdpi.com
Steroidal glycosides are important sources of innovative drugs. The increased diversification
of steroidal glycosides will expand the probability of discovering active molecules. It is an …
of steroidal glycosides will expand the probability of discovering active molecules. It is an …
Characterization of Three Paris polyphylla Glycosyltransferases from Different UGT Families for Steroid Functionalization
W Song, C Zhang, J Wu, J Qi, X Hua, L Kang… - ACS Synthetic …, 2022 - ACS Publications
Plant steroid glycosides, such as phytosterol glycosides, steroidal saponins, and steroidal
glycoalkaloids, are natural products with great pharmaceutical values. In this study, we …
glycoalkaloids, are natural products with great pharmaceutical values. In this study, we …
Functional and Structural Dissection of a Plant Steroid 3-O-Glycosyltransferase Facilitated the Engineering Enhancement of Sugar Donor Promiscuity
W Huang, Y He, R Jiang, Z Deng, F Long - ACS Catalysis, 2022 - ACS Publications
Cardiotonic steroids (CTSs) are ancient and effective clinical drugs for treating heart failure.
Glycosylation of the CTS, especially at the C-3 position, is of great significance in nowadays …
Glycosylation of the CTS, especially at the C-3 position, is of great significance in nowadays …
Cloning and characterization of a glycosyltransferase from Catharanthus roseus for glycosylation of cardiotonic steroids and phenolic compounds
C Wen, W Huang, MM He, WL Deng, HH Yu - Biotechnology letters, 2020 - Springer
Objectives To characterize a glycosyltransferase (UGT74AN3) from Catharanthus roseus
and investigate its specificity toward cardiotonic steroids and phenolic compounds. Results …
and investigate its specificity toward cardiotonic steroids and phenolic compounds. Results …
Glycodiversifying Testosterone with a Promiscuous Glycosyltransferase OsSGT2 from Ornithogalum saundersiae
YN Liu, LL Hong, M Liu, QC Guo… - ACS Synthetic Biology, 2021 - ACS Publications
The diversity expansion of testosterone17-O-β-glycosides (TGs) will increase the probability
of screening more active molecules from their acetylated derivatives with anticancer …
of screening more active molecules from their acetylated derivatives with anticancer …
Synthesis of rhamnosylated diosgenyl glucosides as mimetics of cytostatic steroidal saponins from Ornithogalum saundersiae and Galtonia candicans
R Suhr, P Pfefferkorn, S Weingarten… - Organic & biomolecular …, 2003 - pubs.rsc.org
The synthesis of mimetic 3 of the steroid saponins 1 and 2 was investigated. As a substitute
for the complex 22-homo-23-nor-steroid moieties A and B in 1 and 2 diosgenin C was …
for the complex 22-homo-23-nor-steroid moieties A and B in 1 and 2 diosgenin C was …