Zebrafish (Danio rerio) are aquatic vertebrates with significant homology to their terrestrial
counterparts. While zebrafish have a centuries-long track record in developmental and …

The zebrafish skeleton shares many similarities with human and other vertebrate skeletons.
Over the past years, work in zebrafish has provided an extensive understanding of the basic …

The zebrafish is as an important vertebrate animal model system for studying developmental
processes, gene functions and signalling pathways. It is also used as a model system for the …

The skeleton is a specialized tissue that, together with cartilage, makes up the skeletal
system that confers multiple mechanical and biological functions, such as providing a …

While genome-wide association studies (GWAS) have revolutionized our understanding of
the genetic architecture of skeletal diseases, animal models are required to identify causal …

The development of high-throughput sequencing and genome-wide association studies
allows us to deduce the genetic factors underlying diseases much more rapidly than …

Developmental osteogenesis and pathologies of mineralized tissues are areas of intense
investigations in the mammalian field, but different from other areas of organ formation and …

Small teleost fish such as zebrafish and medaka are increasingly studied as models for
human skeletal diseases. Efficient new genome editing tools combined with advances in the …

Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …