Molecular profiling demonstrates modulation of immune cell function and matrix remodeling during luteal rescue

CK Hughes, SW Maalouf, WS Liu… - Biology of …, 2019 - academic.oup.com
The corpus luteum (CL) is essential for maintenance of pregnancy in all mammals and luteal
rescue, which occurs around day 16–19 in the cow, is necessary to maintain luteal …

Temporal changes in the corpus luteum during early pregnancy reveal regulation of pathways that enhance steroidogenesis and suppress luteolytic mechanisms

CHK Hughes, EK Inskeep, JL Pate - Biology of reproduction, 2020 - academic.oup.com
Although rescue of the corpus luteum (CL) is required for pregnancy, luteal function during
maternal recognition of pregnancy remains largely unexplored. CL were collected from …

Pregnancy-induced changes in the transcriptome of the bovine corpus luteum during and after embryonic interferon-tau secretion

MA Mezera, W Li, MC Wiltbank - Biology of Reproduction, 2021 - academic.oup.com
Understanding luteal maintenance during early pregnancy is of substantial biological and
practical importance. Characterizing effects of early pregnancy, however, has historically …

Transcriptome analysis reveals differences in mechanisms regulating cessation of luteal function in pregnant and non-pregnant dogs

S Zatta, H Rehrauer, A Gram, A Boos, MP Kowalewski - BMC genomics, 2017 - Springer
Background In the domestic dog, corpora lutea (CL) are the only source of progesterone
(P4), both in pregnant and non-pregnant cycles because there is no placental …

Early transcriptome responses of the bovine midcycle corpus luteum to prostaglandin F2α includes cytokine signaling

H Talbott, X Hou, F Qiu, P Zhang, C Guda, F Yu… - Molecular and cellular …, 2017 - Elsevier
In ruminants, prostaglandin F2alpha (PGF2α)-mediated luteolysis is essential prior to
estrous cycle resumption, and is a target for improving fertility. To deduce early PGF2α …

Insights from two independent transcriptomic studies of the bovine corpus luteum during pregnancy

CHK Hughes, MA Mezera, MC Wiltbank… - Journal of animal …, 2022 - academic.oup.com
Several recent studies have used transcriptomics to investigate luteal changes during the
maternal recognition of the pregnancy period in ruminants. Although these studies have …

Downregulated luteolytic pathways in the transcriptome of early pregnancy bovine corpus luteum are mimicked by interferon-tau in vitro

R Basavaraja, JN Drum, J Sapuleni, L Bibi… - BMC genomics, 2021 - Springer
Background Maintenance of the corpus luteum (CL) beyond the time of luteolysis is
essential for establishing pregnancy. Identifying the distinct features of early pregnancy CL …

Pregnancy-associated genes contribute to antiluteolytic mechanisms in ovine corpus luteum

JJ Romero, AQ Antoniazzi… - Physiological …, 2013 - journals.physiology.org
The hypothesis that ovine luteal gene expression differs due to pregnancy status and day of
estrous cycle was tested. RNA was isolated from corpora lutea (CL) on days 12 and 14 of …

The adequate corpus luteum: miR-96 promotes luteal cell survival and progesterone production

BT Mohammed, SD Sontakke… - The Journal of …, 2017 - academic.oup.com
Context: Inadequate progesterone production from the corpus luteum is associated with
pregnancy loss. Data available in model species suggest important roles of microRNAs …

Genomic profiling of bovine corpus luteum maturation

S Kfir, R Basavaraja, N Wigoda, S Ben-Dor, I Orr… - PLoS …, 2018 - journals.plos.org
To unveil novel global changes associated with corpus luteum (CL) maturation, we analyzed
transcriptome data for the bovine CL on days 4 and 11, representing the developing vs …