Long wavelength–emissive Ru (II) metallacycle–based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment

Y Xu, C Li, X Ma, W Tuo, L Tu, X Li… - Proceedings of the …, 2022 - National Acad Sciences
Ruthenium (Ru) complexes are developed as latent emissive photosensitizers for cancer
and pathogen photodiagnosis and therapy. Nevertheless, most existing Ru complexes are …

Rationally designed Ru (ii)-metallacycle chemo-phototheranostic that emits beyond 1000 nm

C Li, Y Xu, L Tu, M Choi, Y Fan, X Chen, JL Sessler… - Chemical …, 2022 - pubs.rsc.org
Ruthenium complexes are emerging as potential complements to platinum drugs. They also
show promise as photo-diagnostic and therapeutic agents. However, most ruthenium …

Construction of emissive ruthenium (II) metallacycle over 1000 nm wavelength for in vivo biomedical applications

Y Xu, C Li, S Lu, Z Wang, S Liu, X Yu, X Li… - Nature …, 2022 - nature.com
Although Ru (II)-based agents are expected to be promising candidates for substituting Pt-
drug, their in vivo biomedical applications are still limited by the short excitation/emission …

NIR‐II Emissive Ru (II) Metallacycle Assisting Fluorescence Imaging and Cancer Therapy

Y Fan, C Li, S Bai, X Ma, J Yang, X Guan, Y Sun - Small, 2022 - Wiley Online Library
Despite the success of emissive Ruthenium (Ru) agents in biomedicine, problems such as
the visible‐light excitation/emission and single chemo‐or phototherapy modality still hamper …

Acceptor engineering of metallacycles with high phototoxicity indices for safe and effective photodynamic therapy

C Li, L Tu, J Yang, C Liu, Y Xu, J Li, W Tuo… - Chemical …, 2023 - pubs.rsc.org
Although metallacycle-based photosensitizers have attracted increasing attention in
biomedicine, their clinical application has been hindered by their inherent dark toxicity and …

Heterometallic Ru–Pt metallacycle for two-photon photodynamic therapy

Z Zhou, J Liu, TW Rees, H Wang, X Li… - Proceedings of the …, 2018 - National Acad Sciences
As an effective and noninvasive treatment of various diseases, photodynamic therapy (PTD)
relies on the combination of light, a photosensitizer, and oxygen to generate cytotoxic …

Luminescent and photofunctional transition metal complexes: From molecular design to diagnostic and therapeutic applications

LCC Lee, KKW Lo - Journal of the American Chemical Society, 2022 - ACS Publications
There has been emerging interest in the exploitation of the photophysical and
photochemical properties of transition metal complexes for diagnostic and therapeutic …

Design of a Metallacycle‐Based Supramolecular Photosensitizer for In Vivo Image‐Guided Photodynamic Inactivation of Bacteria

Y Xu, W Tuo, L Yang, Y Sun, C Li, X Chen… - Angewandte …, 2022 - Wiley Online Library
Bacterial infection is one of the greatest threats to public health. In vivo real‐time monitoring
and effective treatment of infected sites through non‐invasive techniques, remain a …

Engineered metallacycle‐based supramolecular Photosensitizers for effective Photodynamic Therapy

L Tu, C Li, X Xiong, J Hyeon Kim, Q Li, L Mei… - Angewandte …, 2023 - Wiley Online Library
Although metallacycle‐based supramolecular photosensitizers (PSs) have attracted
increasing attention in biomedicine, their clinical translation is still hindered by their inherent …

Ru(II) Dyads Derived from 2-(1-Pyrenyl)-1H-imidazo[4,5-f][1,10]phenanthroline: Versatile Photosensitizers for Photodynamic Applications

M Stephenson, C Reichardt, M Pinto… - The Journal of …, 2014 - ACS Publications
Combining the best attributes of organic photosensitizers with those of coordination
complexes is an elegant way to achieve prolonged excited state lifetimes in Ru (II) dyads …