[HTML][HTML] Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy …
AA Potdar, S Dube, T Naito, G Botwin, T Haritunians… - medRxiv, 2020 - ncbi.nlm.nih.gov
Abstract Angiotensin-Converting Enzyme 2 (ACE2) has been identified as the host receptor
for SARS-coronavirus 2 (SARS-CoV-2) which has infected millions world-wide and likely …
for SARS-coronavirus 2 (SARS-CoV-2) which has infected millions world-wide and likely …
Increased colonic expression of ACE2 associates with poor prognosis in Crohn's disease
T Toyonaga, KC Araba, MM Kennedy, BP Keith… - Scientific Reports, 2021 - nature.com
The host receptor for SARS-CoV-2, angiotensin-converting enzyme 2 (ACE2), is highly
expressed in small intestine. Our aim was to study colonic ACE2 expression in Crohn's …
expressed in small intestine. Our aim was to study colonic ACE2 expression in Crohn's …
Down-regulation of colonic ACE2 expression in patients with inflammatory bowel disease responding to anti-TNF therapy: implications for COVID-19
XZ Li, Y Qiu, L Jeffery, F Liu, R Feng, JS He… - Frontiers in …, 2021 - frontiersin.org
Background and Aims: Angiotensin-converting enzyme II (ACE2) is the key molecule for
understanding the pathophysiology of COVID-19. The risk of COVID-19 and impact of …
understanding the pathophysiology of COVID-19. The risk of COVID-19 and impact of …
Altered intestinal ACE2 levels are associated with inflammation, severe disease, and response to anti-cytokine therapy in inflammatory bowel disease
AA Potdar, S Dube, T Naito, K Li, G Botwin… - Gastroenterology, 2021 - Elsevier
Background And Aims The host receptor for severe acute respiratory syndrome coronavirus
2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small bowel (SB). Our …
2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small bowel (SB). Our …
Intestinal receptor of SARS-CoV-2 in inflamed IBD tissue seems downregulated by HNF4A in ileum and upregulated by interferon regulating factors in colon
B Verstockt, S Verstockt… - Journal of Crohn's …, 2021 - academic.oup.com
Background Patients with inflammatory bowel disease [IBD] are considered
immunosuppressed, but do not seem more vulnerable for COVID-19. Nevertheless …
immunosuppressed, but do not seem more vulnerable for COVID-19. Nevertheless …
Unraveling the role of ACE2, the binding receptor for SARS-CoV-2, in inflammatory bowel disease
M Ferreira-Duarte, MM Estevinho… - Inflammatory Bowel …, 2020 - academic.oup.com
Abstract Angiotensin-converting enzyme 2 (ACE2) has been highlighted for its role as a
receptor for SARS-CoV-2, responsible for the current COVID-19 pandemic. This review …
receptor for SARS-CoV-2, responsible for the current COVID-19 pandemic. This review …
Age, inflammation, and disease location are critical determinants of intestinal expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in inflammatory bowel …
Methods We compared RNA expression of ACE2 and TMPRSS2 in blood (paired-end
sequencing), ileal, and colonic mucosal biopsies (microarray) from 138 patients with …
sequencing), ileal, and colonic mucosal biopsies (microarray) from 138 patients with …
Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2–related disease
M Suárez-Fariñas, M Tokuyama, G Wei, R Huang… - Gastroenterology, 2021 - Elsevier
Background and Aims The presence of gastrointestinal symptoms and high levels of viral
RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS …
RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS …
Expression of SARS-CoV-2 entry molecules ACE2 and TMPRSS2 in the gut of patients with IBD
JF Burgueno, A Reich, H Hazime… - Inflammatory bowel …, 2020 - academic.oup.com
Background Patients with inflammatory bowel disease (IBD) have intestinal inflammation
and are treated with immune-modulating medications. In the face of the coronavirus disease …
and are treated with immune-modulating medications. In the face of the coronavirus disease …
Lessons from COVID-19, ACE2, and intestinal inflammation: could a virus trigger chronic intestinal inflammation?
TP Hanrahan, JS Lubel, M Garg - Clinical Gastroenterology and …, 2021 - cghjournal.org
We read with interest the comprehensive review by D'Amico et al 1 on diarrhea during
coronavirus disease-19 (COVID-19) infection, caused by severe acute respiratory syndrome …
coronavirus disease-19 (COVID-19) infection, caused by severe acute respiratory syndrome …
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