Therapeutic oxygen delivery by perfluorocarbon-based colloids

MP Krafft, JG Riess - Advances in colloid and interface science, 2021 - Elsevier
After the protocol-related indecisive clinical trial of Oxygent, a perfluorooctylbromide/
phospholipid nanoemulsion, in cardiac surgery, that often unduly assigned the observed …

Understanding the Fundamentals of Perfluorocarbons and Perfluorocarbon Emulsions Relevant to In Vivo Oxygen Delivery

JG Riess - Artificial cells, blood substitutes, and biotechnology, 2005 - Taylor & Francis
The unique behavior of perfluorocarbons (PFCs), including their high oxygen dissolving
capacity, hydrophobic and lipophobic character, and extreme inertness, derive directly, in a …

Alleviating tumor hypoxia with perfluorocarbon-based oxygen carriers

MP Krafft - Current Opinion in Pharmacology, 2020 - Elsevier
Highlights•PFCs efficiently deliver O 2 to tumor tissues, and can alleviate hypoxia.•PFC-
based O 2 nanocarriers increase 1 O 2 lifetime, enhancing PDT/SDT, radiotherapy and …

Perfluorocarbon-based oxygen delivery

JG Riess - Artificial cells, blood substitutes, and biotechnology, 2006 - Taylor & Francis
The basic properties of perfluorocarbons (PFCs) and PFC emulsions relevant to their use as
oxygen delivery systems are briefly reviewed. The key issues related to the selection of an …

Oxygen delivery from fluorocarbon emulsions-aspects of convective and diffusive transport

NS Faithfull - Biomaterials, Artificial Cells and Immobilization …, 1992 - Taylor & Francis
Perfluorocarbons (PFCs) deliver oxygen due to their physical characteristics and the
convective delivery to tissues; this has been amply demonstrated in numerous animal …

[HTML][HTML] Perfluorocarbon-based oxygen carriers: from physics to physiology

J Jägers, A Wrobeln, KB Ferenz - Pflügers Archiv-European Journal of …, 2021 - Springer
Developing biocompatible, synthetic oxygen carriers is a consistently challenging task that
researchers have been pursuing for decades. Perfluorocarbons (PFC) are fascinating …

Intracellular pH measurements using perfluorocarbon nanoemulsions

MJ Patrick, JM Janjic, H Teng, MR O'Hear… - Journal of the …, 2013 - ACS Publications
We report the synthesis and formulation of unique perfluorocarbon (PFC) nanoemulsions
enabling intracellular pH measurements in living cells via fluorescent microscopy and flow …

Perfluorocarbon-loaded micro and nanosystems for medical imaging: A state of the art

D Cosco, E Fattal, M Fresta, N Tsapis - Journal of Fluorine Chemistry, 2015 - Elsevier
Perfluorocarbons (PFCs) are fluorinated compounds widely used in the past as oxygen
carriers. They have been the focus of research as contrast agents for ultrasonography and …

Perfluorocarbon nanoemulsions for quantitative molecular imaging and targeted therapeutics

MM Kaneda, S Caruthers, GM Lanza… - Annals of biomedical …, 2009 - Springer
A broad array of nanomaterials is available for use as contrast agents for molecular imaging
and drug delivery. Due to the lack of endogenous background signal in vivo and the high …

Fluorinated blood substitutes and oxygen carriers

KC Lowe - Journal of Fluorine Chemistry, 2001 - Elsevier
Perfluorochemicals (PFCs) are highly fluorinated, inert organic compounds that can dissolve
large volumes of O2 and other respiratory gases. PFCs are unreactive in the body and …