Objective The purpose of the present study is to investigate whether angiopoietin-like 4
(ANGPTL4) can promote angiogenesis and neurogenesis following stroke, as well as to …

Angiogenic factors play an important role in protecting, repairing, and reconstructing vessels
after ischemic stroke. In the brains of transient focal cerebral ischemic mice, we observed a …

Aims Given the impact of vascular injuries and oedema on brain damage caused during
stroke, vascular protection represents a major medical need. We hypothesized that …

Aims Given the risk of blood-brain barrier damage (BBB) caused by ischemic and tissue
plasminogen activator thrombolysis, the preservation of vascular integrity is important …

Background Angiopoietin-like 4 (ANGPTL4) is neuroprotective when administered acutely
for the treatment of cerebral ischemia. The aim of the present study was to evaluate the …

An angiogenesis factor, angiopoietin-1 (Ang1), is associated with the blood-brain barrier
(BBB) disruption after focal cerebral ischemia. However, whether hemorrhagic …

Angiopoietin-like protein (Angptl) 1, a member of the angiopoietin-related protein family,
modulates angiogenesis but little else is known of its physiological role. We found that …

Ischemic stroke is one of the leading causes of death in the world, and thus is a major public
health concern. Atherosclerosis, also known as atherogenesis, is a crucial risk factor for …

Background and Purpose—Studies in rodent models suggest that upregulating angiopoietin-
1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association …

Ischemic stroke is a leading cause of death and disability worldwide. Several reports
suggest that acute inflammation after ischemia-reperfusion exacerbates brain damage; …