Antiviral strategies against human metapneumovirus: Targeting the fusion protein

A Van Den Bergh, B Bailly, P Guillon, M von Itzstein… - Antiviral Research, 2022 - Elsevier
Human metapneumoviruses have emerged in the past decades as an important global
pathogen that causes severe upper and lower respiratory tract infections. Children under the …

Ten years of human metapneumovirus research

F Feuillet, B Lina, M Rosa-Calatrava, G Boivin - Journal of clinical virology, 2012 - Elsevier
Described for the first time in 2001, human metapneumovirus (hMPV) has become one of
the main viral pathogens responsible for acute respiratory tract infections in children but also …

Identification and evaluation of a highly effective fusion inhibitor for human metapneumovirus

C Deffrasnes, ME Hamelin, GA Prince… - Antimicrobial agents …, 2008 - Am Soc Microbiol
Human metapneumovirus (hMPV) can cause acute upper and lower respiratory tract
infections that are particularly severe in young children, elderly subjects, and …

[HTML][HTML] Human metapneumovirus: review of an important respiratory pathogen

S Panda, NK Mohakud, L Pena, S Kumar - International journal of …, 2014 - Elsevier
Human metapneumovirus (hMPV), discovered in 2001, most commonly causes upper and
lower respiratory tract infections in young children, but is also a concern for elderly subjects …

A recombinant human monoclonal antibody to human metapneumovirus fusion protein that neutralizes virus in vitro and is effective therapeutically in vivo

JV Williams, Z Chen, G Cseke, DW Wright… - Journal of …, 2007 - Am Soc Microbiol
Human metapneumovirus (hMPV) is a recently discovered paramyxovirus that is a major
cause of lower-respiratory-tract disease. hMPV is associated with more severe disease in …

Human metapneumovirus: a ubiquitous and long-standing respiratory pathogen

MÈ Hamelin, G Boivin - The Pediatric infectious disease journal, 2005 - journals.lww.com
Background: Human metapneumovirus (hMPV) is a recently described human pathogen first
identified in respiratory specimens of young children suffering from respiratory syndromes …

A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein

M Ballegeer, RC van Scherpenzeel, T Delgado… - Mbio, 2024 - Am Soc Microbiol
Human metapneumovirus (hMPV) is a leading cause of viral lower respiratory tract disease
in children and adults. The hMPV fusion protein F is a trimeric class I fusion protein that is …

Human metapneumovirus: mechanisms and molecular targets used by the virus to avoid the immune system

JA Soto, NMS Gálvez, FM Benavente… - Frontiers in …, 2018 - frontiersin.org
Human metapneumovirus (hMPV) is a respiratory virus, first reported the year 2001. Since
then, it has been described as one of the main etiological agents that causes acute lower …

Human Metapneumovirus: lessons learned over the first decade

V Schildgen, B van den Hoogen… - Clinical microbiology …, 2011 - Am Soc Microbiol
It has been 10 years since human metapneumovirus (HMPV) was identified as a causative
agent of respiratory illness in humans. Since then, numerous studies have contributed to a …

Recent vaccine development for human metapneumovirus

J Ren, T Phan, X Bao - Journal of General Virology, 2015 - microbiologyresearch.org
Human metapneumovirus (hMPV) and respiratory syncytial virus, its close family member,
are two major causes of lower respiratory tract infection in the paediatric population. hMPV is …