Mouse models for Huntington's Disease (HD) and HD patients demonstrate motor and
behavioral dysfunctions, such as progressive loss of coordination and memory, and share …

Huntington's disease (HD) is an autosomal dominant, progressive, and fatal
neurodegenerative disorder caused by an expanded polyglutamine cytosine–adenine …

Despite important advances in understanding and elucidating the molecular and
mechanistic pathways that mediate progression in Huntington's disease (HD), effective …

Huntington's disease (HD) is caused by a genetic mutation that results in polyglutamine
expansion in the N-terminal regions of huntingtin. As a result, this polyQ expansion leads to …

The identification of the mutation causing Huntington's disease (HD) has led to the
generation of a large number of mouse models. These models are used to further enhance …

To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage
have important effects on disease-related transcriptional dysfunction, we compared the …

A milestone in Huntington's disease (HD) research is represented by the identification of the
causative gene. With the genetics at hand, a series of transgenic cellular and animal models …

Huntington's disease is an autosomal dominant neurodegenerative disorder that is
characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for …

One of the roadblocks to developing effective therapeutics for Huntington disease (HD) is
the lack of animal models that develop progressive clinical traits comparable to those seen …

An accepted prerequisite for clinical trials of a compound in humans is the successful
alleviation of the disease in animal models. For some diseases, however, successful …