The alarming increase of resistance against multiple currently available antibiotics is leading
to a rapid lose of treatment options against infectious diseases. Since the antibiotic …

Pharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to
establish rational dosage regimens of antimicrobial agents in human and veterinary …

ABSTRACT A pharmacokinetic-pharmacodynamic (PKPD) model that characterizes the full
time course of in vitro time-kill curve experiments of antibacterial drugs was here evaluated …

Interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics
(PD) of antimicrobial agents has increased over recent years. Since the appearance 2 years …

Over the last decades, the interest in the relationships between the pharmacokinetics (PK)
and pharmacodynamics (PD) of antimicrobial agents has increased and, therefore, the use …

Because of increasing antimicrobial resistance and the shortage of new antibiotics, there is
a growing need to optimize the use of old and new antibiotics. Modelling of the …

Pharmacokinetic-pharmacodynamic (PKPD) modeling and simulation has evolved as an
important tool for rational drug development and drug use, where developed models …

Over the last decade much insight has been gained in the relationships between dosing
regimens of antimicrobials and bacterial eradication and clinical efficacy. These …

ABSTRACT In June 2017, The National Institute of Allergy and Infectious Diseases, part of
the National Institutes of Health, organized a workshop entitled “Pharmacokinetics …

The path of new compounds from discovery to bedside is long and costly and a large
majority of compounds never make it to the market. To improve drug development, better …