The architectural design of our kidneys is amazingly complex, and culminates in the 3D
structure of the glomerular filter. During filtration, plasma passes through a sieve consisting …

From recent data, a novel concept of a highly dynamic slit protein complex is emerging. Slit
diaphragm proteins are contributing to the regulation of cell polarity, cell survival and …

Diseases of the glomerular filter of the kidney are a leading cause of end-stage renal failure.
Recent studies have emphasized the critical role of the slit diaphragm of podocytes for the …

Podocytes are unique cells with a complex cellular organization. With respect to their
cytoarchitecture, podocytes may be divided into three structurally and functionally different …

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

Podocytes are highly specialized cells of the kidney glomerulus that wrap around capillaries
and that neighbor cells of the Bowman's capsule. When it comes to glomerular filtration …

Background: Podocyte biology is a developing science that promises to help improve
understanding of the mechanistic nature of multiple diseases associated with proteinuria …

Dysfunction of slit diaphragm, a cell–cell junction of glomerular podocytes, is involved in the
development of proteinuria in several glomerular diseases. Slit diaphragm should be a …

The filtration of blood in the kidney which is crucial for mammalian life is determined by the
slit-diaphragm, a cell-cell junction between the foot processes of renal podocytes. The slit …

Almost all mammalian cell types have morphologies that are uniquely tailored to their
physiological functions. This immense variation in cell shape depends on an underlying …