Our goal has been to develop ways to tolerize the mature immune system to any defined
antigen. In this report we show that peripheral (post‐thymic) T cells of mice can become …

Induction of transplantation tolerance with certain therapeutic nondepleting monoclonal
antibodies can lead to a robust state of peripheral “dominant” tolerance. Regulatory CD4+ T …

We studied the interactions of male-specific T cell receptor (TCR)-alpha/beta-transgenic
(TG) cells with different concentrations of male antigen in vivo. We constructed mouse …

Although the phenomenon of T cell‐mediated suppression is well established, particularly in
experimental models of transplantation, the mechanisms involved in this form of …

T cell tolerance can be induced in adult mice by injection of soluble antigenic peptide. The
underlying mechanism has been difficult to establish in normal mice due to the low …

The avian embryo has provided an appropriate model to study the ontogeny of the primary
lymphoid organs, thymus and bursa of Fabricius. By using the quail-chick marker system the …

Establishment of antigen-specific tolerance among mature T cells has been a long debated,
yet poorly understood issue. In this study we have used transgenic mice bearing a class II …

BACKGROUND The mechanism of immune tolerance is both one of the most studied and
one of the most controversial fields of immunological research. The first attempt at proposing …

The mechanisms that determine whether receptor stimulation leads to lymphocyte tolerance
versus activation remain poorly understood. We have used rat insulin promoter (RIP)-gp/P14 …

Mice given short courses of anti‐CD4 and anti‐CD8 monoclonal antibodies became tolerant
of allogeneic skin grafted at the same time. Tolerance could be obtained without Tcell …