Mitochondrial dysfunction arises from an inadequate number of mitochondria, an inability to
provide necessary substrates to mitochondria, or a dysfunction in their electron transport and …

Mitochondria supply energy for physiological function and they participate in the regulation
of other cellular events including apoptosis, calcium homeostasis, and production of reactive …

MicroRNAs (miRNAs) are short, single-stranded, non-coding RNA molecules that act as post-
transcriptional gene regulators. They can inhibit target protein-coding genes, through …

Neurodegenerative diseases are debilitating and currently incurable conditions causing
severe cognitive and motor impairments, defined by the progressive deterioration of …

MicroRNAs (miRNAs) are known as the master regulators of gene expression, and for the
last two decades our knowledge of their functional reach keeps expanding. Recent studies …

The cellular processes are controlled by a narrow range of mRNA and proteins levels,
where small RNAs (sRNAs) known as miRNAs play a critical role. The spatial and temporal …

Background Mitochondria, essential to the cell homeostasis maintenance, are central to the
intrinsic apoptotic pathway and their dysfunction is associated with multiple diseases …

Abstract microRNAs (miRNAs) are small, single-stranded noncoding RNA molecules
involved in posttranscriptional control of gene expression of a wide number of genes …

Mitochondria are important organelles in cellular metabolism. Several crucial metabolic
pathways such as the energy producing electron transport chain or the tricarboxylic acid …

Mitochondria play several vital roles in the brain cells, especially in neurons to provide
synaptic energy (ATP), Ca2+ homeostasis, Reactive Oxygen Species (ROS) production …