Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery

J Zhou, M Li, Q Chen, X Li, L Chen, Z Dong… - Nature …, 2022 - nature.com
Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore,
eliminating ROS in the inflammatory site by antioxidant enzymes such as catalase and …

Stimulation-responsive mucoadhesive probiotics for inflammatory bowel disease treatment by scavenging reactive oxygen species and regulating gut microbiota

QX Huang, JL Liang, CH Yang, K Li, MT Niu, JX Fan… - Biomaterials, 2023 - Elsevier
Inflammatory bowel disease (IBD) is characterized by the high level of reactive oxygen
species (ROS) and highly dysfunctional intestinal flora. Here, a stimulation-responsive …

Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the Gut Microbiome

J Xu, J Xu, T Shi, Y Zhang, F Chen, C Yang… - Advanced …, 2023 - Wiley Online Library
Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …

An oral “Super probiotics” with versatile self-assembly adventitia for enhanced intestinal colonization by autonomous regulating the pathological microenvironment

J Yang, G Zhang, X Yang, M Peng, S Ge, S Tan… - Chemical Engineering …, 2022 - Elsevier
Transplanting beneficial bacteria to gut microbiome can positively modulate microbiome
composition and is a promising strategy to prevent and treat diseases. However, oral …

Prodrug integrated envelope on probiotics to enhance target therapy for ulcerative colitis

K Zhang, L Zhu, Y Zhong, L Xu, C Lang… - Advanced …, 2023 - Wiley Online Library
Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders
of the gut microbiota. Probiotics‐based therapy positively regulating the community structure …

Mucoadhesive probiotic backpacks with ROS nanoscavengers enhance the bacteriotherapy for inflammatory bowel diseases

J Liu, Y Wang, WJ Heelan, Y Chen, Z Li, Q Hu - Science advances, 2022 - science.org
Inflammatory bowel diseases (IBDs) are often associated with elevated levels of reactive
oxygen species (ROS) and highly dysregulated gut microbiota. In this study, we synthesized …

Nanoprobiotics for remolding the pro-inflammatory microenvironment and microbiome in the treatment of colitis

J Li, M Sun, L Liu, W Yang, A Sun, J Yu, D Liu… - Nano Letters, 2023 - ACS Publications
Despite the great progress of current bacterially based biotherapeutics, their unsatisfying
efficacy and underlying safety problems have limited their clinical application. Herein …

Modified prebiotic-based “shield” armed probiotics with enhanced resistance of gastrointestinal stresses and prolonged intestinal retention for synergistic alleviation of …

A Xie, H Ji, Z Liu, Y Wan, X Zhang, H Xiong, SP Nie… - ACS …, 2023 - ACS Publications
Oral administration of probiotics is a promising method to alleviate inflammatory bowel
diseases (IBDs). However, gastrointestinal environmental sensitivity and inferior intestinal …

A synthetic probiotic engineered for colorectal cancer therapy modulates gut microbiota

Y Chung, Y Ryu, BC An, YS Yoon, O Choi, TY Kim… - Microbiome, 2021 - Springer
Background Successful chemoprevention or chemotherapy is achieved through targeted
delivery of prophylactic agents during initial phases of carcinogenesis or therapeutic agents …

Physiologically Inspired Mucin Coated Escherichia coli Nissle 1917 Enhances Biotherapy by Regulating the Pathological Microenvironment to Improve Intestinal …

X Yang, J Yang, Z Ye, G Zhang, W Nie, H Cheng… - ACS …, 2022 - ACS Publications
The delivery of probiotics to the microbiota is a promising method to prevent and treat
diseases. However, oral probiotics will suffer from gastrointestinal insults, especially the …