Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery
J Zhou, M Li, Q Chen, X Li, L Chen, Z Dong… - Nature …, 2022 - nature.com
Reactive oxygen species (ROS) play vital roles in intestinal inflammation. Therefore,
eliminating ROS in the inflammatory site by antioxidant enzymes such as catalase and …
eliminating ROS in the inflammatory site by antioxidant enzymes such as catalase and …
Stimulation-responsive mucoadhesive probiotics for inflammatory bowel disease treatment by scavenging reactive oxygen species and regulating gut microbiota
QX Huang, JL Liang, CH Yang, K Li, MT Niu, JX Fan… - Biomaterials, 2023 - Elsevier
Inflammatory bowel disease (IBD) is characterized by the high level of reactive oxygen
species (ROS) and highly dysfunctional intestinal flora. Here, a stimulation-responsive …
species (ROS) and highly dysfunctional intestinal flora. Here, a stimulation-responsive …
Probiotic‐inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the Gut Microbiome
Microbiota‐based therapeutics offer innovative strategies to treat inflammatory bowel
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …
diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the …
An oral “Super probiotics” with versatile self-assembly adventitia for enhanced intestinal colonization by autonomous regulating the pathological microenvironment
J Yang, G Zhang, X Yang, M Peng, S Ge, S Tan… - Chemical Engineering …, 2022 - Elsevier
Transplanting beneficial bacteria to gut microbiome can positively modulate microbiome
composition and is a promising strategy to prevent and treat diseases. However, oral …
composition and is a promising strategy to prevent and treat diseases. However, oral …
Prodrug integrated envelope on probiotics to enhance target therapy for ulcerative colitis
K Zhang, L Zhu, Y Zhong, L Xu, C Lang… - Advanced …, 2023 - Wiley Online Library
Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders
of the gut microbiota. Probiotics‐based therapy positively regulating the community structure …
of the gut microbiota. Probiotics‐based therapy positively regulating the community structure …
Mucoadhesive probiotic backpacks with ROS nanoscavengers enhance the bacteriotherapy for inflammatory bowel diseases
Inflammatory bowel diseases (IBDs) are often associated with elevated levels of reactive
oxygen species (ROS) and highly dysregulated gut microbiota. In this study, we synthesized …
oxygen species (ROS) and highly dysregulated gut microbiota. In this study, we synthesized …
Nanoprobiotics for remolding the pro-inflammatory microenvironment and microbiome in the treatment of colitis
J Li, M Sun, L Liu, W Yang, A Sun, J Yu, D Liu… - Nano Letters, 2023 - ACS Publications
Despite the great progress of current bacterially based biotherapeutics, their unsatisfying
efficacy and underlying safety problems have limited their clinical application. Herein …
efficacy and underlying safety problems have limited their clinical application. Herein …
Modified prebiotic-based “shield” armed probiotics with enhanced resistance of gastrointestinal stresses and prolonged intestinal retention for synergistic alleviation of …
Oral administration of probiotics is a promising method to alleviate inflammatory bowel
diseases (IBDs). However, gastrointestinal environmental sensitivity and inferior intestinal …
diseases (IBDs). However, gastrointestinal environmental sensitivity and inferior intestinal …
A synthetic probiotic engineered for colorectal cancer therapy modulates gut microbiota
Y Chung, Y Ryu, BC An, YS Yoon, O Choi, TY Kim… - Microbiome, 2021 - Springer
Background Successful chemoprevention or chemotherapy is achieved through targeted
delivery of prophylactic agents during initial phases of carcinogenesis or therapeutic agents …
delivery of prophylactic agents during initial phases of carcinogenesis or therapeutic agents …
Physiologically Inspired Mucin Coated Escherichia coli Nissle 1917 Enhances Biotherapy by Regulating the Pathological Microenvironment to Improve Intestinal …
X Yang, J Yang, Z Ye, G Zhang, W Nie, H Cheng… - ACS …, 2022 - ACS Publications
The delivery of probiotics to the microbiota is a promising method to prevent and treat
diseases. However, oral probiotics will suffer from gastrointestinal insults, especially the …
diseases. However, oral probiotics will suffer from gastrointestinal insults, especially the …