Microbial metabolites control the thymic development of mucosal-associated invariant T cells
F Legoux, D Bellet, C Daviaud, Y El Morr, A Darbois… - Science, 2019 - science.org
How the microbiota modulate immune functions remains poorly understood. Mucosal-
associated invariant T (MAIT) cells are implicated in mucosal homeostasis and absent in …
associated invariant T (MAIT) cells are implicated in mucosal homeostasis and absent in …
MAIT cells are imprinted by the microbiota in early life and promote tissue repair
MG Constantinides, VM Link, S Tamoutounour… - Science, 2019 - science.org
INTRODUCTION The microbiota promotes the maturation and homeostasis of the immune
system, in part through the release of microbial products. Early-life microbial colonization …
system, in part through the release of microbial products. Early-life microbial colonization …
Molecular mechanisms of lineage decisions in metabolite-specific T cells
F Legoux, J Gilet, E Procopio, K Echasserieau… - Nature …, 2019 - nature.com
Mucosal-associated invariant T cells (MAIT cells) recognize the microbial metabolite 5-(2-
oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU) presented by the MHC class Ib …
oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU) presented by the MHC class Ib …
A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage
Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives
presented by the antigen-presenting molecule MR1. Here we defined three developmental …
presented by the antigen-presenting molecule MR1. Here we defined three developmental …
[HTML][HTML] Single-cell analysis of human MAIT cell transcriptional, functional and clonal diversity
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize microbial
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …
metabolites through a semi-invariant T cell receptor (TCR). Major questions remain …
Early-life imprinting of unconventional T cells and tissue homeostasis
MG Constantinides, Y Belkaid - Science, 2021 - science.org
BACKGROUND In addition to providing antimicrobial immunity, the immune system governs
numerous aspects of host physiology, in part through the coordinated action of tissue …
numerous aspects of host physiology, in part through the coordinated action of tissue …
[PDF][PDF] MAIT cell development and functions: the microbial connection
F Legoux, M Salou, O Lantz - Immunity, 2020 - cell.com
Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved T cell subset,
which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of …
which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of …
The proliferation of human mucosal-associated invariant T cells requires a MYC-SLC7A5-glycolysis metabolic axis
N Kedia-Mehta, MM Pisarska, C Rollings, C O'Neill… - Science …, 2023 - science.org
Mucosal-associated invariant T (MAIT) cells are an abundant population of innate T cells
that recognize bacterial ligands and play a key role in host protection against bacterial and …
that recognize bacterial ligands and play a key role in host protection against bacterial and …
Thymic development of gut-microbiota-specific T cells
Humans and their microbiota have coevolved a mutually beneficial relationship in which the
human host provides a hospitable environment for the microorganisms and the microbiota …
human host provides a hospitable environment for the microorganisms and the microbiota …
[HTML][HTML] Mucosal-associated invariant T cell–rich congenic mouse strain allows functional evaluation
Y Cui, K Franciszkiewicz, YK Mburu… - The Journal of …, 2015 - Am Soc Clin Investig
Mucosal-associated invariant T cells (MAITs) have potent antimicrobial activity and are
abundant in humans (5%–10% in blood). Despite strong evolutionary conservation of the …
abundant in humans (5%–10% in blood). Despite strong evolutionary conservation of the …