Conformational ensembles of the human intrinsically disordered proteome
Intrinsically disordered proteins and regions (collectively, IDRs) are pervasive across
proteomes in all kingdoms of life, help to shape biological functions and are involved in …
proteomes in all kingdoms of life, help to shape biological functions and are involved in …
[HTML][HTML] On the potential of machine learning to examine the relationship between sequence, structure, dynamics and function of intrinsically disordered proteins
K Lindorff-Larsen, BB Kragelund - Journal of Molecular Biology, 2021 - Elsevier
Intrinsically disordered proteins (IDPs) constitute a broad set of proteins with few uniting and
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …
many diverging properties. IDPs—and intrinsically disordered regions (IDRs) interspersed …
[HTML][HTML] Structural biases in disordered proteins are prevalent in the cell
Intrinsically disordered proteins and protein regions (IDPs) are prevalent in all proteomes
and are essential to cellular function. Unlike folded proteins, IDPs exist in an ensemble of …
and are essential to cellular function. Unlike folded proteins, IDPs exist in an ensemble of …
Introduction to intrinsically disordered proteins and regions
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are
fascinating dynamic conformational ensembles that are observed under physiological …
fascinating dynamic conformational ensembles that are observed under physiological …
[HTML][HTML] CIDER: resources to analyze sequence-ensemble relationships of intrinsically disordered proteins
AS Holehouse, RK Das, JN Ahad, MOG Richardson… - Biophysical journal, 2017 - cell.com
Intrinsically disordered proteins and regions (IDPs) represent a large class of proteins that
are defined by conformational heterogeneity and lack of persistent tertiary/secondary …
are defined by conformational heterogeneity and lack of persistent tertiary/secondary …
Design of intrinsically disordered protein variants with diverse structural properties
Intrinsically disordered proteins (IDPs) perform a broad range of functions in biology,
suggesting that the ability to design IDPs could help expand the repertoire of proteins with …
suggesting that the ability to design IDPs could help expand the repertoire of proteins with …
[图书][B] Structure and function of intrinsically disordered proteins
The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …
classical structure-function paradigm that equates function with a well-defined 3D structure …
Direct prediction of intrinsically disordered protein conformational properties from sequence
Intrinsically disordered regions (IDRs) are ubiquitous across all domains of life and play a
range of functional roles. While folded domains are generally well-described by a stable 3D …
range of functional roles. While folded domains are generally well-described by a stable 3D …
SOURSOP: A Python package for the analysis of simulations of intrinsically disordered proteins
Conformational heterogeneity is a defining hallmark of intrinsically disordered proteins and
protein regions (IDRs). The functions of IDRs and the emergent cellular phenotypes they …
protein regions (IDRs). The functions of IDRs and the emergent cellular phenotypes they …
[HTML][HTML] Sequence-to-conformation relationships of disordered regions tethered to folded domains of proteins
Intrinsically disordered proteins and regions (IDPs/IDRs) are characterized by well-defined
sequence-to-conformation relationships (SCRs). These relationships refer to the sequence …
sequence-to-conformation relationships (SCRs). These relationships refer to the sequence …