Pannexins are large-pore ion channels with broad expression in the central nervous system
(CNS). The channels function by releasing large signaling molecules, such ATP and …

Pannexin 1 (Panx1) forms plasma membrane ion channels that are widely expressed
throughout the body. Panx1 activation results in the release of nucleotides such as …

Abstract Pannexin‐1 (Panx1) is a large pore membrane channel with unique conduction
properties ranging from non‐selective ion permeability to the extracellular release of …

Three family members compose the pannexin family of channel-forming glycoproteins
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …

Pannexin 1 (Panx1) channels are generally represented as non-selective, large-pore
channels that release ATP. Emerging roles have been described for Panx1 in mediating …

In less than a decade, a small family of channel-forming glycoproteins, named pannexins,
have captured the interest of many biologists, in large part due to their association with …

Pannexin 1 (Px1, Panx1) and pannexin 2 (Px2, Panx2) form large-pore nonselective
channels in the plasma membrane of cells and were suggested to play a role in the …

Pannexins form channels at the plasma membrane surface that establish a pathway for
communication between the cytosol of individual cells and their extracellular environment …

Abstract Pannexin 1 (PANX1) subunits form oligomeric plasma membrane channels that
mediate nucleotide release for purinergic signalling, which is involved in diverse …

Pannexins are a family of integral membrane proteins with distinct post-translational
modifications, sub-cellular localization and tissue distribution. Panx1 is the most studied and …