Depression is the most common disabling psychiatric disease, with a high prevalence and
mortality. Chronic unpredictable mild stress (CUMS) is a well-accepted method used to …

Background Prolonged exposure to stress triggers depression, threatening human health.
Thus, to thoroughly understand the underlying pathophysiologic mechanism of chronic …

Background The molecular alterations underlying the pathogenesis of depression have not
been systematically defined. Increasing evidence suggests that hippocampus metabolism is …

Depression is a common and highly debilitating psychiatric illness. However, the
pathophysiology of depression is not fully understood. In this study Sprague-Dawley rats …

This study analyzed the effects of aerobic exercise on endogenous serum metabolites in
response to chronic unpredictable mild stress (CUMS) using a rat model, aiming to identify …

Chronic stress is closely linked to clinical depression, which could be assessed by a chronic
unpredictable mild stress (CUMS) animal model. We present here a GC/MS-based …

Background: Depressive disorder is the leading cause of disability and suicidality
worldwide. Metabolites are considered indicators and regulators of depression. However …

Depression is a type of complex psychiatric disorder with long-term, recurrent bouts, and its
etiology remains largely unknown. Here, an integrated approach utilizing 1H NMR and …

Major depressive disorder (MDD) is a prevalent and serious mental disorder with high rates
of suicide and disability. However, the underlying pathogenesis of MDD is complicated and …

Depression is a complex disease characterized by a series of pathological changes.
Research on depression is mainly focused on the changes in brain, but not on liver …