Neurotoxicity of polychlorinated biphenyls and related organohalogens

IN Pessah, PJ Lein, RF Seegal, SK Sagiv - Acta neuropathologica, 2019 - Springer
Halogenated organic compounds are pervasive in natural and built environments. Despite
restrictions on the production of many of these compounds in most parts of the world through …

[HTML][HTML] Evidence implicating non-dioxin-like congeners as the key mediators of polychlorinated biphenyl (PCB) developmental neurotoxicity

C Klocke, PJ Lein - International journal of molecular sciences, 2020 - mdpi.com
Despite being banned from production for decades, polychlorinated biphenyls (PCBs)
continue to pose a significant risk to human health. This is due to not only the continued …

Developmental neurotoxicity of persistent organic pollutants: an update on childhood outcome

SA Berghuis, AF Bos, PJJ Sauer, E Roze - Archives of toxicology, 2015 - Springer
Organohalogens are persistent organic pollutants that have a wide range of chemical
application. There is growing evidence that several of these chemical compounds interfere …

The developmental neurotoxicity of legacy vs. contemporary polychlorinated biphenyls (PCBs): similarities and differences

C Klocke, S Sethi, PJ Lein - Environmental Science and Pollution …, 2020 - Springer
Although banned from production for decades, PCBs remain a significant risk to human
health. A primary target of concern is the developing brain. Epidemiological studies link PCB …

[HTML][HTML] Polychlorinated biphenyls (PCBs): risk factors for autism spectrum disorder?

HK Panesar, CL Kennedy, KP Keil Stietz, PJ Lein - Toxics, 2020 - mdpi.com
Autism spectrum disorder (ASD) includes a group of multifactorial neurodevelopmental
disorders defined clinically by core deficits in social reciprocity and communication …

Polychlorinated biphenyls (PCBs) and neurological development in children: a systematic review

N Ribas-Fito, M Sala, M Kogevinas… - Journal of Epidemiology & …, 2001 - jech.bmj.com
BACKGROUND Polychlorinated biphenyls (PCBs) are complex mixtures of persistent
contaminants that are widespread in the environment. Newborns are exposed across the …

Prenatal exposure to polychlorinated biphenyls: a neuropsychologic analysis

O Boucher, G Muckle, CH Bastien - Environmental health …, 2009 - ehp.niehs.nih.gov
Objectives A large body of literature documents the effects of prenatal exposure to
polychlorinated biphenyls (PCBs) on cognitive development of children. Despite this fact, no …

Epidemiological and laboratory evidence of PCB-lnduced neurotoxicity

RF Seegal - Critical reviews in toxicology, 1996 - Taylor & Francis
The purpose of this review is to provide a selective, but critical, assessment of important
findings derived from both epidemiological and laboratory studies suggesting that:(1) …

Lead and PCBs as risk factors for attention deficit/hyperactivity disorder

PA Eubig, A Aguiar, SL Schantz - Environmental health …, 2010 - ehp.niehs.nih.gov
Objectives Attention deficit/hyperactivity disorder (ADHD) is the most frequently diagnosed
neurobehavioral disorder of childhood, yet its etiology is not well understood. In this review …

Assessment of polychlorinated biphenyls and their hydroxylated metabolites in postmortem human brain samples: age and brain region differences

X Li, MM Hefti, RF Marek, KC Hornbuckle… - … science & technology, 2022 - ACS Publications
Exposure to polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-
PCBs) has been implicated in neurodevelopmental disorders. However, the distribution of …