[HTML][HTML] N-terminal tagging of RNA Polymerase II shapes transcriptomes more than C-terminal alterations
A Callan-Sidat, E Zewdu, M Cavallaro, J Liu… - Iscience, 2024 - cell.com
Summary RNA polymerase II (Pol II) has a C-terminal domain (CTD) that is unstructured,
consisting of a large number of heptad repeats, and whose precise function remains …
consisting of a large number of heptad repeats, and whose precise function remains …
[HTML][HTML] RNA Pol II length and disorder enable cooperative scaling of transcriptional bursting
Summary RNA polymerase II (RNA Pol II) contains a disordered C-terminal domain (CTD)
whose length enigmatically correlates with genome size. The CTD is crucial to eukaryotic …
whose length enigmatically correlates with genome size. The CTD is crucial to eukaryotic …
Mammalian NET-seq analysis defines nascent RNA profiles and associated RNA processing genome-wide
The transcription cycle of RNA polymerase II (Pol II) correlates with changes to the
phosphorylation state of its large subunit C-terminal domain (CTD). We recently developed …
phosphorylation state of its large subunit C-terminal domain (CTD). We recently developed …
Single-molecule nascent RNA sequencing identifies regulatory domain architecture at promoters and enhancers
Abstract Eukaryotic RNA polymerase II (Pol II) has been found at both promoters and distal
enhancers, suggesting additional functions beyond mRNA production. To understand this …
enhancers, suggesting additional functions beyond mRNA production. To understand this …
Transcription activation depends on the length of the RNA polymerase II C‐terminal domain
A Sawicka, G Villamil, M Lidschreiber, X Darzacq… - The EMBO …, 2021 - embopress.org
Abstract Eukaryotic RNA polymerase II (Pol II) contains a tail‐like, intrinsically disordered
carboxy‐terminal domain (CTD) comprised of heptad‐repeats, that functions in coordination …
carboxy‐terminal domain (CTD) comprised of heptad‐repeats, that functions in coordination …
PRO-IP-seq tracks molecular modifications of engaged Pol II complexes at nucleotide resolution
A Vihervaara, P Versluis, SV Himanen, JT Lis - Nature Communications, 2023 - nature.com
Abstract RNA Polymerase II (Pol II) is a multi-subunit complex that undergoes covalent
modifications as transcription proceeds through genes and enhancers. Rate-limiting steps of …
modifications as transcription proceeds through genes and enhancers. Rate-limiting steps of …
Simplicity is the ultimate sophistication—crosstalk of post-translational modifications on the rna polymerase ii
The highly conserved C-terminal domain (CTD) of the largest subunit of RNA polymerase II
comprises a consensus heptad (Y 1 S 2 P 3 T 4 S 5 P 6 S 7) repeated multiple times …
comprises a consensus heptad (Y 1 S 2 P 3 T 4 S 5 P 6 S 7) repeated multiple times …
RNA polymerase II clustering through carboxy-terminal domain phase separation
M Boehning, C Dugast-Darzacq, M Rankovic… - Nature structural & …, 2018 - nature.com
The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is an intrinsically disordered
low-complexity region that is critical for pre-mRNA transcription and processing. The CTD …
low-complexity region that is critical for pre-mRNA transcription and processing. The CTD …
Chemical-genomic dissection of the CTD code
JR Tietjen, DW Zhang, JB Rodríguez-Molina… - Nature structural & …, 2010 - nature.com
Sequential modifications of the RNA polymerase II (Pol II) C-terminal domain (CTD)
coordinate the stage-specific association and release of cellular machines during …
coordinate the stage-specific association and release of cellular machines during …
Emerging views on the CTD code
DW Zhang, JB Rodríguez-Molina… - Genetics research …, 2012 - Wiley Online Library
The C‐terminal domain (CTD) of RNA polymerase II (Pol II) consists of conserved
heptapeptide repeats that function as a binding platform for different protein complexes …
heptapeptide repeats that function as a binding platform for different protein complexes …