Photon-and Proton-Mediated Biological Effects: What Has Been Learned?

E Jumaniyazova, D Smyk, P Vishnyakova… - Life, 2022 - mdpi.com
The current understanding of the effects of radiation is gradually becoming broader.
However, it still remains unclear why some patients respond to radiation with a pronounced …

Biological considerations when comparing proton therapy with photon therapy

H Paganetti, P Van Luijk - Seminars in radiation oncology, 2013 - Elsevier
Owing to the limited availability of data on the outcome of proton therapy, treatments are
generally optimized based on broadly available data on photon-based treatments. However …

Normal tissue injury induced by photon and proton therapies: Gaps and opportunities

PG Prasanna, K Rawojc, C Guha… - International Journal of …, 2021 - Elsevier
Despite technological advances in radiotherapy and cancer treatment, patients still
experience adverse effects. Proton therapy has emerged as a valuable radiotherapy …

Clinical progress in proton radiotherapy: biological unknowns

L Vanderwaeren, R Dok, K Verstrepen, S Nuyts - Cancers, 2021 - mdpi.com
Simple Summary Proton radiation therapy is a more recent type of radiotherapy that uses
proton beams instead of classical photon or X-rays beams. The clinical benefit of proton …

“Radiobiology of Proton Therapy”: Results of an international expert workshop

A Lühr, C von Neubeck, J Pawelke, A Seidlitz… - Radiotherapy and …, 2018 - Elsevier
The physical properties of proton beams offer the potential to reduce toxicity in tumor-
adjacent normal tissues. Toward this end, the number of proton radiotherapy facilities has …

Biological effects of proton radiation: an update

S Girdhani, R Sachs, L Hlatky - Radiation protection dosimetry, 2015 - academic.oup.com
Proton radiation provides significant dosimetric advantages when compared with gamma
radiation due to its superior energy deposition characteristics. Although the physical aspects …

[HTML][HTML] Proton versus photon radiation therapy: a clinical review

Z Chen, MM Dominello, MC Joiner… - Frontiers in …, 2023 - frontiersin.org
While proton radiation therapy offers substantially better dose distribution characteristics
than photon radiation therapy in certain clinical applications, data demonstrating a …

Cellular and molecular effects of protons: apoptosis induction and potential implications for cancer therapy

C Di Pietro, S Piro, G Tabbi, M Ragusa, V Di Pietro… - Apoptosis, 2006 - Springer
Due to their ballistic precision, apoptosis induction by protons could be a strategy to
specifically eliminate neoplastic cells. To characterize the cellular and molecular effects of …

Proton beams in cancer treatments: clinical outcomes and dosimetric comparisons with photon therapy

J Doyen, AT Falk, V Floquet, J Hérault… - Cancer treatment …, 2016 - Elsevier
Purpose To review current evidence of the role of proton therapy (PT) in other tumors than
skull base, sinusal/parasinusal, spinal and pediatric tumors; to determine medico-economic …

Proton radiobiology

F Tommasino, M Durante - Cancers, 2015 - mdpi.com
In addition to the physical advantages (Bragg peak), the use of charged particles in cancer
therapy can be associated with distinct biological effects compared to X-rays. While heavy …