IN RECENT years increased importance has been attached to corpus luteum dysfunctions
as causes of habitual abortion, sterility and menorrhagia (1). The reported investigations to …

T HE first gonadotropic principle to be demonstrated clearly was that derived from human
chorionic elements and present in the urine of pregnant women. Since its demonstration in …

During the luteal phase of the menstrual cycle, rhesus monkeys (M. mulatto) were treated
with 50 IU HCG in saline or saline alone, administered intramuscularly. The ten daily …

Recent advance in biologic research by Hisaw and Fevold, Corner, and others, has made
the corpus luteum hormone available as a pure product for medical use. We wish to …

The first actual experiments to establish the corpus luteum as an endocrine glandwere made
byFraenkel'in I 903. He found that removal of the corpora lutea in the first few days of …

Our understanding of the mechanism and physiology of the menstrual cycle has been
greatly clarified in recent years, from the chemical aspect by the preparation and use of …

Human chorionic gonadotropin (hCG) was administered to pseudopregnant rats with 4-day-
old corpora lutea and to normal women on days 16 to 18 following onset of menses. In the …

T HE presence of the corpus luteum during pregnancy led Born, and later Fraenkel (1, 2), to
investigate the influence of the corpus luteum on the implantation of the embryo. Ancel and …

In previous papers of the present series1 we have described the preparation and effects of
extracts of the corpus luteum. These extracts, when injected into recently spayed female …

The human corpus luteum is maintained and continues to function throughout pregnancy.
Human chorionic gonadotropin (HCG) plays a major role in the maintenance of the corpus …