Nicotine in senescence and atherosclerosis

AM Centner, PG Bhide, G Salazar - Cells, 2020 - mdpi.com
Cigarette smoke is a known exacerbator of age-related pathologies, such as cardiovascular
disease (CVD), atherosclerosis, and cellular aging (senescence). However, the role of …

[HTML][HTML] Nicotine exacerbates atherosclerosis through a macrophage-mediated endothelial injury pathway

CY Mao, DJ Li, E Zhou, JF Zhang, CQ Wang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Evidence suggests that nicotine intake promotes atherosclerosis. We enrolled 100 patients
with coronary heart disease (CHD) and found that plaque burden, TXNIP expression, and …

[HTML][HTML] Oxidative stress and accelerated vascular aging: implications for cigarette smoking

A Csiszar, A Podlutsky, MS Wolin… - … in bioscience: a …, 2009 - ncbi.nlm.nih.gov
Cigarette smoking is the major cause of preventable morbidity and mortality in the United
States and constitutes a major risk factor for atherosclerotic vascular disease, including …

Nicotine: Regulatory roles and mechanisms in atherosclerosis progression

X Fu, T Zong, P Yang, L Li, S Wang, Z Wang… - Food and Chemical …, 2021 - Elsevier
Smoking is an independent risk factor for atherosclerosis. The smoke produced by tobacco
burning contains more than 7000 chemicals, among which nicotine is closely related to the …

The role of nicotine in the pathogenesis of atherosclerosis

J Lee, JP Cooke - Atherosclerosis, 2011 - atherosclerosis-journal.com
Smoking is a major preventable risk factor for atherosclerosis. Exposure to cigarette smoke
activates a number of mechanisms predisposing to atherosclerosis, including thrombosis …

Aging Enhances Susceptibility to Cigarette Smoke–Induced Inflammation through Bronchiolar Chemokines

C Moriyama, T Betsuyaku, Y Ito… - American journal of …, 2010 - atsjournals.org
Cigarette smoking and aging are major risk factors for chronic obstructive pulmonary
disease. An unsolved question is whether elderly lungs are particularly vulnerable to …

Oxidative stress and inflammation: elucidating mechanisms of smoking-attributable pathology for therapeutic targeting

TA Addissouky, IET El Sayed, MMA Ali, Y Wang… - Bulletin of the National …, 2024 - Springer
Background Tobacco smoking remains a major preventable cause of disease and death
worldwide. Combustible cigarettes release thousands of chemicals that can initiate …

Cigarette smoke-induced respiratory response: insights into cellular processes and biomarkers

SR Cha, J Jang, SM Park, SM Ryu, SJ Cho, SR Yang - Antioxidants, 2023 - mdpi.com
Cigarette smoke (CS) poses a significant risk factor for respiratory, vascular, and organ
diseases owing to its high content of harmful chemicals and reactive oxygen species (ROS) …

Nicotine: specific role in angiogenesis, proliferation and apoptosis

A Cardinale, C Nastrucci, A Cesario… - Critical reviews in …, 2012 - Taylor & Francis
Nowadays, tobacco smoking is the cause of~ 5–6 million deaths per year, counting 31% and
6% of all cancer deaths (affecting 18 different organs) in middle-aged men and women …

Chronic exposure to nicotine impairs cholinergic angiogenesis

H Konishi, J Wu, JP Cooke - Vascular medicine, 2010 - journals.sagepub.com
Cholinergic angiogenesis is mediated by an endothelial nicotinic acetylcholine receptor (EC
nAChR). Short-term administration of nicotine stimulates angiogenesis via EC nAChRs. The …