Infections caused by biofilm-forming bacteria are a major threat to hospitalized patients and
the main cause of chronic obstructive pulmonary disease and cystic fibrosis. There is an …

Biofilm-associated infections have emerged as a significant public health challenge due to
their persistent nature and increased resistance to conventional treatment methods. The …

Bacterial biofilms play a key role during infections, which are associated with an increased
morbidity and mortality. The classical antibiotic therapy cannot eradicate biofilm-related …

Biofilms are matrix-enclosed communities of bacteria that show increased antibiotic
resistance and the capability to evade the immune system. They can cause recalcitrant …

Pseudomonas aeruginosa infection in cystic fibrosis (CF) is a major complication which
aggravates the disease complexity and progression. The improvement of antimicrobial …

Purpose To investigate the effect of the antibiotic release profiles of levofloxacin-loaded
polymeric nanoparticles on their antibacterial efficacy against E. coli biofilm cells. Methods …

The efficacy of antibody-functionalized poly (d, l-lactide-co-glycolide)(PLGA) nanoparticles
(NPs), prepared by nanoprecipitation, carrying rifampicin (RIF) against planktonic, sessile …

Since the birth of civilization, people have recognized that infectious microbes cause serious
and often fatal diseases in humans. One of the most dangerous characteristics of …

Conventional antibiotic treatment is in most cases insufficient to eradicate biofilm-related
infections, resulting in high risk of treatment failure and recurrent infections. Recent studies …

Background Considering the timeline required for the development of novel antimicrobial
drugs, increased attention should be given to repurposing old drugs and improving …