It is now recognized that a number of excipients previously considered to be “inert” have the
capacity to alter drug oral bioavailability through a range of in vivo effects. The various …

Traditionally, excipients have been considered in drug development from the perspective of
their influence on drug solubility, manufacturability, and ability to control in vitro and in vivo …

Excipients represent diverse classes of molecules, small molecules or macromolecules, with
versatile structures within a given class and are from natural, semi-synthetic and synthetic …

The potential for certain excipients to impact drug absorption is the subject of numerous
publications. Reflecting this, current Biopharmaceutics Classification System (BCS) …

Although the use of excipients is widespread, a thorough understanding of the drug
interaction potential of these compounds remains a frequent topic of current research. Not …

The Biopharmaceutics Classification System (BCS), based on aqueous solubility and
intestinal permeability, has been widely used to predict drug absorption during …

The increasing number of new chemical entities is bringing new challenges to the field of
drug delivery. These drugs present bioavailability issues that are frequently associated with …

Excipients used in drug formulations at clinically safe levels have been considered to be
pharmacologically inert; however, numerous studies have suggested that many solubilizing …

Introduction Excipients are necessary to develop oral dosage forms of any Active
Pharmaceutical Ingredient (API). Traditionally, excipients have been considered inactive …

The objective of this review article is to summarize literature data pertinent to potential
excipient effects on intestinal drug permeability and transit. Despite the use of excipients in …