Parkinson's disease (PD) is a progressive and chronic neurodegenerative disease of the
central nervous system. Early treatment for PD is efficient; however, long-term systemic …

Sustained and safe delivery of dopamine across the blood brain barrier (BBB) is a major
hurdle for successful therapy in Parkinson's disease (PD), a neurodegenerative disorder …

Abstract Parkinson's disease (PD), a neurodegenerative disease that shows a high
incidence in older individuals, is becoming increasingly prevalent. Unfortunately, there is no …

The combination of excessive reactive oxygen species (ROS) levels, neuroinflammation,
and pathogenic protein aggregation disrupt the homeostasis of brain microenvironment …

Neurodegenerative diseases (NDs) represent a heterogeneous group of aging-related
disorders featured by progressive impairment of motor and/or cognitive functions, often …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by degeneration of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) resulting in dopamine …

Despite research efforts to discover new drugs for Parkinson treatment, the majority of
candidates fail in preclinical and clinical trials due to inadequate pharmacokinetic …

Parkinson's disease (PD) is a neurodegenerative disease characterized by the death of
dopaminergic (DA) neurons and currently cannot be cured. One selected antisense …

Noninvasive treatments to treat the brain-related disorders have been paying more
significant attention and it is an emerging topic. However, overcoming the blood brain barrier …

Abstract Parkinson's disease (PD), although being the second most prevalent
neurodegenerative disease (ND) encounters lack of definitive treatment and challenges in …