Objective To investigate the characteristics of hematological malignancies in patients with
the SET-CAN fusion gene and provide a literature review. Methods We retrospectively …

Background: The SET-CAN/NUP214 fusion gene resulting from chromosomal del (9)(q34.
11q34. 13) or t (9; 9)(q34; q34) has been found in T-cell acute lymphoblastic leukemia (T …

Abstract SET-CAN/NUP214 fusion is a recurrent event commonly observed in adult male
patients diagnosed with T-cell acute lymphoblastic leukemia (T-ALL) and has occasionally …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy
characterized by the clonal proliferation of T-lineage progenitor cells instead of the normal …

Leukemias are heterogeneous diseases characterized by aberrant hematopoietic stem and
progenitor cells (HSPCs). Oncogenic fusion genes and proteins, produced via gross …

The SET nuclear proto-oncogene (SET)-nucleoporin (NUP) 214 fusion gene, which results
from cryptic t (9; 9)(q34; q34) or del (9)(q34. 11q34. 13), is a rare genetic event in …

SET-NUP214 fusion gene, also known as TAF-1-CAN and SET-CAN, is observed in acute
myeloid leukemia (AML) and T-cell lymphoblastic leukemia (T-ALL). SET-NUP214 fusion in …

Cryptic deletions are occasionally reported in hematologic malignancies. The SET-NUP214
fusion gene has been rarely reported in acute myeloid leukemia, acute undifferentiated …

Fusion genes (FGs) are major molecular biological abnormalities in hematological
malignancies and have become well-established molecular markers for disease …

Aims and background. The SET gene is a target of chromosomal translocations in acute
leukemia and encodes a widely expressed multifunctional phosphoprotein. It has been …