Diabetes is associated with β cell failure. But it remains unclear whether the latter results
from reduced β cell number or function. FoxO1 integrates β cell proliferation with adaptive β …

Pancreatic β cell failure in type 2 diabetes is associated with functional abnormalities of
insulin secretion and deficits of β cell mass. It's unclear how one begets the other. We have …

We review mechanisms of β‐cell failure in type 2 diabetes. A wealth of information indicates
that it is caused by impaired insulin secretion and decreased β‐cell mass. Interestingly …

Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

Type 2 diabetes mellitus is a complex disease characterized by β-cell failure in the setting of
insulin resistance. In early stages of the disease, pancreatic β-cells adapt to insulin …

Over the past two decades, insulin resistance has been considered essential to the
aetiology of type 2 diabetes mellitus (T2DM). However, insulin resistance does not lead to …

Diabetes is associated with decreased pancreatic β-cell function and mass. It is unclear
whether diabetes treatment should aim at restoring β-cell performance/mass or at inducing" …

The mechanisms that regulate pancreatic β cell mass are poorly understood. While
autoimmune and pharmacological destruction of insulin-producing β cells is often …

Recovery of functional β‐cell mass continues to be an ongoing challenge in treating
diabetes. Initial work studying β‐cells suggested apoptotic β‐cell death as a main contributor …

Diabetes is a metabolic disease characterized by hyperglycemia. Over 90% of patients with
diabetes have type 2 diabetes. Pancreatic β-cells are endocrine cells that produce and …