Role of arachidonic acid metabolism in intervertebral disc degeneration: identification of potential biomarkers and therapeutic targets via multi-omics analysis and …
J Tan, M Shi, B Li, Y Liu, S Luo, X Cheng - Lipids in Health and Disease, 2023 - Springer
Background Intervertebral disc degeneration (IVDD) is widely recognized as the primary
etiological factor underlying low back pain, often necessitating surgical intervention as the …
etiological factor underlying low back pain, often necessitating surgical intervention as the …
Metabolomic signature and molecular profile of normal and degenerated human intervertebral disc cells
V Francisco, DA Eldjoudi, M González-Rodríguez… - The Spine Journal, 2023 - Elsevier
BACKGROUND CONTEXT Intervertebral disc degeneration (IVDD) is an incurable, specific
treatment-orphan disease with an increasing burden worldwide. Although great efforts have …
treatment-orphan disease with an increasing burden worldwide. Although great efforts have …
Palmitic acid induces lipid droplet accumulation and senescence in nucleus pulposus cells via ER-stress pathway
X Chen, K Chen, J Hu, Y Dong, M Zheng… - Communications …, 2024 - nature.com
Intervertebral disc degeneration (IDD) is a highly prevalent musculoskeletal disorder
affecting millions of adults worldwide, but a poor understanding of its pathogenesis has …
affecting millions of adults worldwide, but a poor understanding of its pathogenesis has …
SSR1 and CKAP4 as potential biomarkers for intervertebral disc degeneration based on integrated bioinformatics analysis
D Guo, M Zeng, M Yu, J Shang, J Lin, L Liu, K Yang… - JOR …, 2024 - Wiley Online Library
Background Intervertebral disc degeneration (IDD) is a significant cause of low back pain
and poses a significant public health concern. Genetic factors play a crucial role in IDD …
and poses a significant public health concern. Genetic factors play a crucial role in IDD …
[HTML][HTML] Altered Metabolism and Inflammation Driven by Post-translational Modifications in Intervertebral Disc Degeneration
Intervertebral disc degeneration (IVDD) is a prevalent cause of low back pain and a leading
contributor to disability. IVDD progression involves pathological shifts marked by low-grade …
contributor to disability. IVDD progression involves pathological shifts marked by low-grade …
Multiomics analysis reveals the potential of LPCAT1-PC axis as a therapeutic target for human intervertebral disc degeneration
X Chen, K Chen, J Hu, Y Dong, M Zheng, Q Hu… - International Journal of …, 2024 - Elsevier
Intervertebral disc degeneration (IDD) is a highly prevalent musculoskeletal disorder that is
associated with considerable morbidity. However, there is currently no drug available that …
associated with considerable morbidity. However, there is currently no drug available that …
Major ceRNA regulation and key metabolic signature analysis of intervertebral disc degeneration
S Cao, J Li, K Yang, H Li - BMC Musculoskeletal Disorders, 2021 - Springer
Background and objective Intervertebral disc degeneration (IDD) is a complex multifactorial
and irreversible pathological process. In IDD, multiple competing endogenous RNAs …
and irreversible pathological process. In IDD, multiple competing endogenous RNAs …
Integrated proteome sequencing, bulk RNA sequencing and single-cell RNA sequencing to identify potential biomarkers in different grades of intervertebral disc …
X Yang, Y Lu, H Zhou, HT Jiang, L Chu - Frontiers in Cell and …, 2023 - frontiersin.org
Low back pain (LBP) is a prevalent health problem worldwide that affects over 80% of adults
during their lifetime. Intervertebral disc degeneration (IDD) is a well-recognized leading …
during their lifetime. Intervertebral disc degeneration (IDD) is a well-recognized leading …
ATG9A as a potential diagnostic marker of intervertebral disc degeneration: Inferences from experiments and bioinformatics analysis incorporating sc-RNA-seq data
X Tang, S Lin, H Luo, L Wang, J Zhong, J Xiong, H Lv… - Gene, 2024 - Elsevier
Background Disfunctional autophagy plays a pivotal role in Intervertebral Disc Degeneration
(IDD) progression. however, the connection between Autophagy-related gene 9A (ATG9A) …
(IDD) progression. however, the connection between Autophagy-related gene 9A (ATG9A) …
Deciphering the sequential changes of monocytes/macrophages in the progression of IDD with longitudinal approach using single-cell transcriptome
W Li, Y Zhao, Y Wang, Z He, L Zhang, B Yuan… - Frontiers in …, 2023 - frontiersin.org
Intervertebral disk degeneration (IDD) is a chronic inflammatory disease with intricate
connections between immune infiltration and oxidative stress (OS). Complex cell niches …
connections between immune infiltration and oxidative stress (OS). Complex cell niches …
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