Background Exposure to ultraviolet light is a major causative factor in melanoma, although
the relationship between risk and exposure is complex. We hypothesized that the clinical …

There is increasing epidemiological and molecular evidence that cutaneous melanomas
arise through multiple causal pathways. The purpose of this study was to explore the …

Despite the large body of mutational data available for melanoma and epidemiological
studies linking this cancer to ultraviolet radiation (UVR), the fundamental carcinogenic …

In the last decade, significant progress has been made in our understanding of the genetic
alterations in melanocytic tumors. The most exciting finding is the discovery of oncogenic …

Malignant melanomas often contain BRAF or NRAS mutations, but the relationship of these
mutations to ambient UV exposure in combination with phenotypic characteristics is …

Purpose: The mutation load in melanoma is generally high compared with other tumor types
due to extensive UV damage. Translation of exome sequencing data into clinically relevant …

The Clark model for melanoma progression emphasizes a series of histopathological
changes beginning from benign melanocytic nevus to melanoma via dysplastic nevus …

The RAS/mitogen-activated protein kinase pathway sends external growth-promoting
signals to the nucleus. BRAF, a critical serine/threonine kinase in this pathway, is frequently …

Alterations in the RAS signaling cascade are almost uniformly present in melanoma. RAS
itself is only infrequently mutated in melanoma although downstream of RAS lie BRAF on …

In this report, we investigated BRAF/NRAS mutations in samples from a case–control study
of melanoma and a series of benign melanocytic nevi. We evaluated potential associations …