This review summarizes recent findings on peripheral mechanisms underlying the
generation and inhibition of pain. The focus is on events occurring in peripheral injured …

Pain research has uncovered important neuronal mechanisms that underlie clinically
relevant pain states such as inflammatory and neuropathic pain. Importantly, both the …

Pain is an essential physiological defense against danger, be it external, from the
environment, or internal, arising from within the body. The initiation of this acute defensive …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

In Romeo and Juliet, Shakespeare argues that the names of things are not as important as
the thing itself and how we identify it. Hansson's Topical Review [4] asks whether central …

Chronic pain differs from acute pain in that it serves no useful function, causes suffering,
limits activities of daily living, and increases costs of healthcare payments, disability, and …

This is a very exciting time in the field of pain research. Major advances are occurring at
every level of analysis, from development to neural plasticity in the adult and from the …

Advances in the characterization of pain signaling in recent years indicate that distinct
neurophysiological and neurochemical mechanisms contribute to pain arising from injury to …

Although interest in descending modulation of spinal cord function dates back to the time of
Sherrington, the modern era began in the late 1960s when it was shown that focal electrical …

Many studies in several species, including humans, have identified a subset of primary
afferent nerve fibres that are activated by potential or actual tissue-damaging stimuli …