Low-density lipoproteins (LDLs) are a naturally occurring endogenous nanoplatform in
mammalian systems. These nanoparticles (22 nm) specifically transport cholesterol to cells …

Low-density lipoprotein (LDL) provides a highly versatile natural nanoplatform for delivery of
visible or near-infrared fluorescent optical and magnetic resonance imaging (MRI) contrast …

RATIONALE AND OBJECTIVES: Over-expression of low-density lipoprotein receptors
(LDLRs) occurs in many types of malignancies and is related to the requirement for lipids for …

The need for more specific and selective contrast agents for magnetic resonance imaging
motivated us to prepare a new nanoparticle agent based on high-density lipoproteins (HDL) …

Gd-DO3A-diph and Gd-AAZTAC17 are lipophilic magnetic resonance imaging (MRI) agents
that display high affinity for low-density lipoprotein (LDL) particles. However, on binding to …

Background Natural high-density lipoproteins (HDL) possess important physiological
functions to the transport of cholesterol from the peripheral tissues to the liver for metabolic …

A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor
(GdDO3A-OA) was prepared for in vivodetection of atheroplaques. The GdDO3A-OA, when …

Magnetic resonance (MR) contrast agents focusing on special functions are required to
improve cancer diagnosis, particularly in the early stages. Here, we designed multifunctional …

Background Liposomal-based gadolinium (Gd) nanoparticles have elicited significant
interest for use as blood pool and molecular magnetic resonance imaging (MRI) contrast …

Solid lipid nanoparticles (SLNs) have recently emerged as nontoxic, versatile alternatives to
traditional carriers (liposomes, polymeric nanoparticles) for drug delivery. Because SLNs are …