The purpose of this paper is to review human leukocyte antigen G (HLA-G) in the eye, its
role in immune tolerance, and the potential therapeutic use of AAV gene transfer and …

Over 1.5 million individuals suffer from cornea vascularization due to genetic and/or
environmental factors, compromising visual acuity and often resulting in blindness. Current …

Non-infectious uveitis (NIU) is an intractable, recurrent, and painful disease that is a
common cause of vision loss. Available treatments of NIU, such as the use of topical …

Purpose: To study the modulation of immunoregulatory genes in ocular surface epithelial
cells cultured on amniotic membrane (AM). Methods: Microarray analysis was performed in …

purpose. To investigate whether recombinant adeno-associated virus (rAAV) vector–
mediated transgene expression is induced by inflammation in corneal endothelial cells in …

Purpose.: The lacrimal gland (LG) delivers defensive and metabolic factors to the ocular
surface. These functions may be disrupted in several diseases, and for most of them there is …

The eye has been at the forefront of translational gene therapy largely owing to suitable
disease targets, anatomic accessibility, and well-studied immunologic privilege. These …

Uveitis is an important autoimmune disease affecting an estimated 2.3 million Americans.
This disease is manifested by inflammation of the retina mediated by the infiltration of T …

Purpose. We examined the efficacy and cytopathogenicity of adeno-associated (AAV) and
herpes simplex viruses (HSV) as vectors for gene transfer to corneal endothelial cells …

Gene delivery approaches using adeno-associated virus (AAV) vectors are currently the
preferred method for human gene therapy applications and have demonstrated success in …