Single-cell multiomics revealed the dynamics of antigen presentation, immune response and T cell activation in the COVID-19 positive and recovered individuals

P Chattopadhyay, K Khare, M Kumar, P Mishra… - Frontiers in …, 2022 - frontiersin.org
Introduction Despite numerous efforts to describe COVID-19's immunological landscape,
there is still a gap in our understanding of the virus's infections after-effects, especially in the …

Multi-omics integration reveals only minor long-term molecular and functional sequelae in immune cells of individuals recovered from COVID-19

Z Liu, G Kilic, W Li, O Bulut, MK Gupta… - Frontiers in …, 2022 - frontiersin.org
The majority of COVID-19 patients experience mild to moderate disease course and recover
within a few weeks. An increasing number of studies characterized the long-term changes in …

Multiomic immunophenotyping of COVID-19 patients reveals early infection trajectories

Y Su, D Chen, C Lausted, D Yuan, J Choi, C Dai… - BioRxiv, 2020 - biorxiv.org
Host immune responses play central roles in controlling SARS-CoV2 infection, yet remain
incompletely characterized and understood. Here, we present a comprehensive immune …

[HTML][HTML] COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

X Ren, W Wen, X Fan, W Hou, B Su, P Cai, J Li, Y Liu… - Cell, 2021 - cell.com
A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent …

A landscape study on COVID-19 immunity at the single-cell level

R Wei, Z Qin, Q Huang, L Liu, F Cheng… - Frontiers in …, 2022 - frontiersin.org
Since 2019, the coronavirus (COVID-19) has outbroken continuously, spreading
internationally and threatening the public health. However, it was unknown how the disorder …

Identification of distinct immune cell subsets associated with asymptomatic infection, disease severity, and viral persistence in COVID-19 patients

X Wang, H Bai, J Ma, H Qin, Q Zeng, F Hu… - Frontiers in …, 2022 - frontiersin.org
The cell-mediated protective and pathogenic immune responses to SARS-CoV-2 infection
remain largely elusive. Here we identified 76 distinct cell subsets in the PBMC samples that …

Multi-faceted dysregulated immune response for COVID-19 infection explaining clinical heterogeneity

SK Paine, P Choudhury, M Alam, C Bhattacharyya… - Cytokine, 2024 - Elsevier
Clinical heterogeneity and varied prognosis are well noted for SARS-CoV-2 infection.
Altered immune response is a major feature for the adverse prognosis however focus on …

Biomarkers and immune repertoire metrics identified by peripheral blood transcriptomic sequencing reveal the pathogenesis of COVID-19

Y Liu, Y Wu, B Liu, Y Zhang, D San, Y Chen… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection is a global crisis; however, our current …

High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients

W Wang, B Su, L Pang, L Qiao, Y Feng… - Cellular & molecular …, 2020 - nature.com
The outbreak of coronavirus disease 2019 (COVID-19) caused by the new virus SARS-CoV-
2 has been announced as a public health emergency of international concern. 1-3 The …

Single-cell analysis reveals the immune characteristics of myeloid cells and memory T cells in recovered COVID-19 patients with different severities

X Li, M Garg, T Jia, Q Liao, L Yuan, M Li, Z Wu… - Frontiers in …, 2022 - frontiersin.org
Despite many studies on the immune characteristics of Coronavirus disease 2019 (COVID-
19) patients in the progression stage, a detailed understanding of pertinent immune cells in …