Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …

Schizophrenia is a chronic illness affecting approximately 0.5–1% of the world's population.
The etiology of schizophrenia is complex, including multiple genes, and contributing …

Gray matter loss in the cortex is extensive in schizophrenia, especially in the prefrontal-
temporal-network (PTN). Several molecules such as neuregulin-1 (NRG1) and its ErbB4 …

Schizophrenia, a severe and debilitating disorder with a high social burden, affects 1% of
the adult world population. Available therapies are unable to treat all the symptoms, and …

Objective: Decreased density of dendritic spines in adult schizophrenia subjects has been
hypothesized to result from increased pruning of excess synapses in adolescence. In vivo …

Postmortem studies have revealed reduced densities of dendritic spines in the dorsal lateral
prefrontal cortex (DLPFC) of subjects with schizophrenia. However, the molecular …

Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Highlights•Genetic and functional studies have provided important evidence pointing toward
a central role for dendritic spines on the pathogenesis of neuropsychiatric conditions.•Many …

OBJECTIVE: In a previous study the authors found that dendritic spine density was reduced
on prefrontal pyramidal neurons in layer 3 of subjects with schizophrenia. From a neural …

Background The pathophysiological characteristics of schizophrenia appear to involve
altered synaptic connectivity in the dorsolateral prefrontal cortex. Given the central role that …