Parkinson's disease (PD) is the most common movement disorder and the second most
prevalent neurodegenerative disease after Alzheimer's disease. Despite decades of …

Parkinson's disease (PD) is a common neurodegenerative pathology whose major clinical
symptoms are movement disorders. The main pathological characteristics of PD are the …

Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the
pathogenesis of Parkinson's disease. While the normal function of alpha-synuclein is mainly …

Oxidative stress has long been considered a key component contributing to pathologies
associated with brain aging and age-related neurodegenerative diseases. The proposed …

Emerging evidence indicates that cellular senescence could be a critical inducing factor for
aging-associated neurodegenerative disorders. However, the involvement of cellular …

Selective loss of neurons, abnormal protein deposition and neuroinflammation are the
common pathological features of neurodegenerative diseases, and these features are …

Abstract α-Synuclein (α-Syn) is closely related to the pathogenesis of Parkinson's disease
(PD). Under pathological conditions, the conformation of α-syn changes and different forms …

Background: Parkinson's disease (PD) is a multifactorial, chronic, and progressive
neurodegenerative disease. α-Synuclein (α-syn), which is the main protein component of …

Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …

Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …