NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis
HZ Yu, BQ Zhu, L Zhu, S Li… - Neural Regeneration …, 2022 - journals.lww.com
Nuclear receptor subfamily 4 group A1 (NR4A1) is an orphan nuclear receptor, which is
expressed in the majority of cells. NR4A1 expression in peripheral blood mononuclear cells …
expressed in the majority of cells. NR4A1 expression in peripheral blood mononuclear cells …
Nr4a1 plays a crucial modulatory role in Th1/Th17 cell responses and CNS autoimmunity
LM Wang, Y Zhang, X Li, ML Zhang, L Zhu… - Brain, behavior, and …, 2018 - Elsevier
Nuclear receptor4 group A1 (Nr4a1), an orphan nuclear receptor, is down-regulated in
peripheral blood mononuclear cells (MNCs) of individuals with multiple sclerosis (MS), and …
peripheral blood mononuclear cells (MNCs) of individuals with multiple sclerosis (MS), and …
Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines
Y Doi, S Oki, T Ozawa, H Hohjoh… - Proceedings of the …, 2008 - National Acad Sciences
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
mediated by Th17 and Th1 cells. DNA microarray analysis previously showed that NR4A2 …
mediated by Th17 and Th1 cells. DNA microarray analysis previously showed that NR4A2 …
The nuclear receptor Nr4a1 acts as a microglia rheostat and serves as a therapeutic target in autoimmune-driven central nervous system inflammation
T Rothe, N Ipseiz, M Faas, S Lang… - The Journal of …, 2017 - journals.aai.org
Microglia cells fulfill key homeostatic functions and essentially contribute to host defense
within the CNS. Altered activation of microglia, in turn, has been implicated in …
within the CNS. Altered activation of microglia, in turn, has been implicated in …
Potential Roles of Nr4a3-Mediated Inflammation in Immunological and Neurological Diseases
S He, W Jiang, B Jiang, C Yu, G Zhao, Y Li, L Qi… - Molecular …, 2024 - Springer
As a protein of the orphan nuclear receptor Nr4a family, Nr4a3 has no identified natural
ligands. However, its biological activity can be mediated by inducing conformational …
ligands. However, its biological activity can be mediated by inducing conformational …
The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice
C Higashi, A Kawaji, N Tsuda, M Hayashi… - European Journal of …, 2017 - Elsevier
The transcription factor NF-E2-related factor 2 (Nrf2) is a key regulator of cellular defense
mechanisms against oxidative stress. Multiple sclerosis (MS), a chronic inflammatory …
mechanisms against oxidative stress. Multiple sclerosis (MS), a chronic inflammatory …
NR4A1 regulates cerebral ischemia-induced brain injury by regulating neuroinflammation through interaction with NF-κB/p65
YJ Zhang, JR Song, MJ Zhao - Biochemical and Biophysical Research …, 2019 - Elsevier
Stroke is reported as a leading cause of mortality and disability in the world.
Neuroinflammation is significantly induced responding to ischemic stroke, and this process …
Neuroinflammation is significantly induced responding to ischemic stroke, and this process …
[HTML][HTML] Propranolol diminished severity of rat EAE by enhancing immunoregulatory/protective properties of spinal cord microglia
I Pilipović, Z Stojić-Vukanić, I Prijić, N Jasnić… - Neurobiology of …, 2020 - Elsevier
Sympathetic dysfunction is suggested to contribute to development of multiple sclerosis and
experimental autoimmune encephalomyelitis (EAE) alike. Considering important role of …
experimental autoimmune encephalomyelitis (EAE) alike. Considering important role of …
Sulforaphane ameliorates the development of experimental autoimmune encephalomyelitis by antagonizing oxidative stress and Th17-related inflammation in mice
B Li, W Cui, J Liu, R Li, Q Liu, XH Xie, XL Ge… - Experimental …, 2013 - Elsevier
Sulforaphane (SFN) is an organosulfur compound present in vegetables and has potent anti-
oxidant and anti-inflammatory activities. This study was aimed at investigating the effect of …
oxidant and anti-inflammatory activities. This study was aimed at investigating the effect of …
Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis
AS Basso, D Frenkel, FJ Quintana… - The Journal of …, 2008 - Am Soc Clin Investig
Axonal degeneration is an important determinant of progressive neurological disability in
multiple sclerosis (MS). Thus, therapeutic approaches promoting neuroprotection could aid …
multiple sclerosis (MS). Thus, therapeutic approaches promoting neuroprotection could aid …