Nuclear receptor subfamily 4 group A1 (NR4A1) is an orphan nuclear receptor, which is
expressed in the majority of cells. NR4A1 expression in peripheral blood mononuclear cells …

Nuclear receptor4 group A1 (Nr4a1), an orphan nuclear receptor, is down-regulated in
peripheral blood mononuclear cells (MNCs) of individuals with multiple sclerosis (MS), and …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
mediated by Th17 and Th1 cells. DNA microarray analysis previously showed that NR4A2 …

Microglia cells fulfill key homeostatic functions and essentially contribute to host defense
within the CNS. Altered activation of microglia, in turn, has been implicated in …

As a protein of the orphan nuclear receptor Nr4a family, Nr4a3 has no identified natural
ligands. However, its biological activity can be mediated by inducing conformational …

The transcription factor NF-E2-related factor 2 (Nrf2) is a key regulator of cellular defense
mechanisms against oxidative stress. Multiple sclerosis (MS), a chronic inflammatory …

Stroke is reported as a leading cause of mortality and disability in the world.
Neuroinflammation is significantly induced responding to ischemic stroke, and this process …

Sympathetic dysfunction is suggested to contribute to development of multiple sclerosis and
experimental autoimmune encephalomyelitis (EAE) alike. Considering important role of …

Sulforaphane (SFN) is an organosulfur compound present in vegetables and has potent anti-
oxidant and anti-inflammatory activities. This study was aimed at investigating the effect of …

Axonal degeneration is an important determinant of progressive neurological disability in
multiple sclerosis (MS). Thus, therapeutic approaches promoting neuroprotection could aid …