Gastrointestinal cancers represent a heterogeneous complex array of disorders and
diseases. They may be divided into rare inherited forms and more frequent sporadic forms …

Cancers are caused by the sequential accumulation of alterations in genes that control the
growth, differentiation, and other behaviors of cells. It has long been recognized that cancers …

Much of the progress in the understanding of gastrointestinal disorders has continued to
center on the molecular underpinning of gastrointestinal neoplasia in the 21st century. First …

This volume includes the information necessary to understand recent critical advances in the
mechanisms of intestinal tumorigenesis and to comprehend the complexity of the process …

Over the last several decades, our understanding of the cellular and molecular mechanisms
of cancer of the gastrointestinal tract has increased dramatically [1]. Through the analysis of …

The vast majority of cancers are a result of sporadic genetic events; only rare cases (1%)
have an inherited component. Our current understanding of cancer genetics comes largely …

Digestive cancers, such as colorectal cancer, gastric cancer and liver cancer, remain major
threats to human health in coming decades and their epidemiology is under dynamic …

Important pathogenic alterations within established cancers are acquired during the pre-
malignant stage. These genetic alterations can be grouped into specific neoplastic pathways …

Oncogene research over the last century has been one of the major advances in
understanding the molecular biology of malignant disease. Oncogenes are a structurally …

Cancer of the large bowel offers a unique opportunity to understand the events in
carcinogenesis and tumor progression because the biologist has ready access to tissues at …