Human psychopathology is the result of complex and subtle neurobiological alterations.
Categorial DSM or ICD diagnoses do not allow a biologically founded and differentiated …

BackgroundStudies investigating structural brain abnormalities in depression have typically
employed a categorical rather than dimensional approach to depression [ie comparing …

Background Few studies have investigated the relationship between structural brain
abnormalities and dimensions of depressive symptomatology. Methods In the current study …

Background Dimensional approaches in highly prevalent psychiatric disorders like
depression or anxiety could lead to a better understanding of pathogenesis and advantages …

Introduction More than a century of research on the neurobiological underpinnings of major
psychiatric disorders (major depressive disorder [MDD], bipolar disorder [BD], schizophrenia …

Abnormalities in brain structural measures, such as cortical thickness and subcortical
volumes, are observed in patients with major depressive disorder (MDD) who also often …

OBJECTIVE: First, the objective was to test the hypothesis that prefrontal cortical regions
most often reported to be maximally abnormal in studies of major depressive disorder …

Alterations in regional subcortical brain volumes have been investigated as part of the efforts
of an international consortium, ENIGMA, to identify reliable neural correlates of major …

Although anxiety and depression often co-occur and share some clinical features, it is still
unclear if they are neurobiologically distinct or similar processes. In this study, we explored …

The neural networks that putatively modulate aspects of normal emotional behavior have
been implicated in the pathophysiology of mood disorders by converging evidence from …