Cytokines play a central role in the pathophysiology of autoimmune and inflammatory
diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized …

The four Janus kinase (JAK) proteins and the seven Signal Transducers of Activated
Transcription (STAT) mediate intracellular signal transduction downstream of cytokine …

Cytokines are major drivers of autoimmunity, and biologic agents targeting cytokines have
revolutionized the treatment of immune-mediated diseases. Despite the effectiveness of …

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway is
an important intracellular route through which many different extracellular soluble …

Janus kinase (JAK)/signal transducers and activators of transcription (STATs) are a group of
molecules associated with one of the major pathways through which many cytokines exert …

The treatment of rheumatoid arthritis has changed dramatically over the last two decades
since the development of biological disease-modifying anti-rheumatic drugs (bDMARDs) …

Biological therapies directed at proinflammatory cytokines have irrevocably changed the
landscape of treatment of rheumatoid arthritis (RA) and other autoimmune diseases. With …

Rheumatoid arthritis (RA) is classified as an inflammatory, chronic autoimmune and
disabling disease based on the intricate interplay between environmental and genetic …

The discovery of cytokines and their role in immune and inflammatory disease led to the
development of a plethora of targeted biologic therapies. Later, efforts to understand …

Janus kinase (JAK) inhibitors (jakinibs) that target downstream signalling by a large range of
cytokines are effective in treating autoimmune and rheumatic diseases. Newer jakinibs that …