Developmental exposure to polychlorinated biphenyls prevents recovery from noise-induced hearing loss and disrupts the functional organization of the inferior …

BA Ibrahim, JJ Louie, Y Shinagawa, G Xiao… - Journal of …, 2023 - Soc Neuroscience
Exposure to combinations of environmental toxins is growing in prevalence; and therefore,
understanding their interactions is of increasing societal importance. Here, we examined the …

Developmental PCB exposure disrupts synaptic transmission and connectivity in the rat auditory cortex, independent of its effects on peripheral hearing threshold

CM Lee, RN Sadowski, SL Schantz, DA Llano - eneuro, 2021 - eneuro.org
Polychlorinated biphenyls (PCBs) are enduring environmental toxicants and exposure is
associated with neurodevelopmental deficits. The auditory system appears particularly …

Developmental PCB exposure increases susceptibility to audiogenic seizures in adulthood

E Poon, SB Bandara, JB Allen, RN Sadowski… - Neurotoxicology, 2015 - Elsevier
Developmental exposure to polychlorinated biphenyls (PCBs) causes auditory deficits.
Thus, we recently conducted a study to investigate if developmental PCB exposure would …

Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex

T Kenet, RC Froemke, CE Schreiner… - Proceedings of the …, 2007 - National Acad Sciences
Noncoplanar polychlorinated biphenyls (PCBs) are widely dispersed in human environment
and tissues. Here, an exemplar noncoplanar PCB was fed to rat dams during gestation and …

Hearing loss following exposure during development to polychlorinated biphenyls: a cochlear site of action

KM Crofton, DL Ding, R Padich, M Taylor, D Henderson - Hearing research, 2000 - Elsevier
Maternal exposure to polyhalogenated hydrocarbons results in early postnatal
hypothyroxenemia and a low-frequency hearing loss in adult offspring (Goldey et al., 1995a …

Developmental exposure to PCBs, MeHg, or both: long-term effects on auditory function

BE Powers, E Poon, HJK Sable… - Environmental health …, 2009 - ehp.niehs.nih.gov
Background Developmental exposure to polychlorinated biphenyls (PCBs) or
methylmercury (MeHg) can result in a variety of neurotoxic effects, including long-term …

Developmental PCB exposure increases audiogenic seizures and decreases glutamic acid decarboxylase in the inferior colliculus

SB Bandara, PA Eubig, RN Sadowski… - Toxicological …, 2016 - academic.oup.com
Previously, we observed that developmental polychlorinated biphenyl (PCB) exposure
resulted in an increase in audiogenic seizures (AGSs) in rats. However, the rats were …

Perinatal exposure to Aroclor 1254 impairs distortion product otoacoustic emissions (DPOAEs) in rats

RE Lasky, JJ Widholm, KM Crofton… - Toxicological …, 2002 - academic.oup.com
Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that are a
potential health hazard to human and wildlife populations. Low-frequency auditory …

Auditory deficits in rats exposed to an environmental PCB mixture during development

BE Powers, JJ Widholm, RE Lasky… - Toxicological …, 2006 - academic.oup.com
Previous studies have indicated that developmental exposure to polychlorinated biphenyls
(PCBs) may result in hearing impairment in rats. The cochlea is the suggested site of action …

Environmental exposures and hearing loss

R Rosati, S Jamesdaniel - … journal of environmental research and public …, 2020 - mdpi.com
Pollutants that contaminate the natural or built environment adversely affect the health of
living organisms. Although exposure to many of them could be avoided or minimized by …