Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Oncoproteins and tumor-suppressor proteins regulate cell growth and viability. Recent
observations show that phosphoinositide 3-kinase (PtdIns 3-kinase)–Akt signaling promotes …

The PTEN tumor suppressor protein inhibits phosphatidylinositol 3-kinase (PI3K)/Akt
signaling that promotes translocation of Mdm2 into the nucleus. When restricted to the …

The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) tumor suppressor
is a phosphatase that antagonizes the phosphoinositol-3-kinase/AKT signaling pathway and …

The PTEN tumour suppressor gene is induced by the early growth response 1 (EGR1)
transcription factor, which also transactivates p53, p73, and p300/CBP as well as other …

Tumor suppressor activation or reactivation has long been a sought-after, yet elusive,
therapeutic strategy for human cancer. Phosphatase and tensin homolog (PTEN) is one of …

PTEN tumor suppressor is frequently mutated in human cancers and is a negative regulator
of PI3′ K/PKB/Akt-dependent cellular survival. Investigation of the human genomic PTEN …

We show, for the first time, that the tumor suppressor PTEN can have tumor-promoting
properties. We show that PTEN acquires these unexpected properties by enhancing gain-of …

We show in this study that PTEN regulates p53 protein levels and transcriptional activity
through both phosphatase-dependent and-independent mechanisms. The onset of tumor …

Numerous hereditary syndromes caused by mutations in multiple tumor suppressor genes
can cause cancers. Germline mutations in PTEN and p53 tumor suppressor cause Cowden …