The ubiquitin-proteasome system (UPS) is the major machinery mediating specific protein
turnover in eukaryotic cells. By ubiquitylating unwanted, damaged, or harmful proteins and …

Ubiquitination is a highly conserved post-translational modification that regulates protein
trafficking, function, and turnover. Ubiquitin ligases (E3s) conjugate ubiquitin polypeptides …

Various hypotheses have been proposed regarding how chain length, linkage type, position
on substrate, and susceptibility to deubiquitinases (DUBs) affect processing of different …

Protein ubiquitylation plays important roles in many biological activities. Protein
ubiquitylation is a unique process that is mainly controlled by ubiquitin ligases. The ubiquitin …

The reversible post‐translational modification of proteins by ubiquitin and ubiquitin‐like
proteins regulates almost all cellular processes, by affecting protein degradation …

Ubiquitin (Ub) is a highly conserved protein of 76 amino acids that is covalently linked to
target proteins altering their localization, function, or stability. 1-3 Proteins can be modified …

Post-translational modifications such as ubiquitination play important regulatory roles in
several biological processes in eukaryotes. This process could be reversed by …

Ubiquitin (Ub) is a small 76 amino acid long protein that is highly conserved in all
eukaryotes studied to date. In humans, more than 600 ligases are involved in the reversible …

The ubiquitin proteasome system (UPS) is essential in regulating myriad aspects of protein
functions. It is therefore a fundamentally important regulatory mechanism that impacts most if …

Targeted protein degradation (TPD) technology has gradually become widespread in the
past 20 years, which greatly boosts the development of disease treatment. Contrary to small …