A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain

S Muhi, J Osowicki, D O'Brien… - PLOS Neglected …, 2023 - journals.plos.org
Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of
Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines …

Mycobacterium ulcerans challenge strain selection for a Buruli ulcer controlled human infection model

S Muhi, AH Buultjens, JL Porter… - PLOS Neglected …, 2024 - journals.plos.org
Critical scientific questions remain regarding infection with Mycobacterium ulcerans, the
organism responsible for the neglected tropical disease, Buruli ulcer (BU). A controlled …

Mycobacterium ulcerans Mouse Model Refinement for Pre-Clinical Profiling of Vaccine Candidates

A Bénard, C Sala, G Pluschke - PLoS One, 2016 - journals.plos.org
Buruli Ulcer is a neglected tropical disease leading to extensive disabilities and morbidity in
West Africa. In this paper we sought to characterize various strains of Mycobacterium …

Understanding the transmission of Mycobacterium ulcerans: A step towards controlling Buruli ulcer

AJ Muleta, R Lappan, TP Stinear… - PLoS Neglected …, 2021 - journals.plos.org
Mycobacterium ulcerans is the causative agent of Buruli ulcer, a rare but chronic debilitating
skin and soft tissue disease found predominantly in West Africa and Southeast Australia …

Buruli ulcer: The Efficacy of Innate Immune Defense May Be a Key Determinant for the Outcome of Infection With Mycobacterium ulcerans

K Röltgen, G Pluschke - Frontiers in microbiology, 2020 - frontiersin.org
Buruli ulcer (BU) is a neglected, tropical infectious disease of the skin and the subcutaneous
tissue caused by Mycobacterium ulcerans. This pathogen has emerged as a new species …

[PDF][PDF] The immunology of Buruli ulcer

J Fevereiro, AG Fraga, J Pedrosa - Buruli Ulcer: Mycobacterium …, 2019 - library.oapen.org
Buruli ulcer (BU) represents a unique human mycobacteriosis. Caused by Mycobacterium
ulcerans, the disease spectrum is dominated by the activity of mycolactone, a dermanecrotic …

Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model

M Bolz, N Ruggli, N Borel, G Pluschke… - PLoS neglected tropical …, 2016 - journals.plos.org
Background Buruli ulcer is a neglected tropical disease of the skin that is caused by infection
with Mycobacterium ulcerans. We recently established an experimental pig (Sus scrofa) …

Spontaneous Healing of Mycobacterium ulcerans Lesions in the Guinea Pig Model

R Silva-Gomes, E Marcq, G Trigo… - PLoS neglected …, 2015 - journals.plos.org
Buruli Ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans infection.
BU is characterized by a wide range of clinical forms, including non-ulcerative cutaneous …

Linking the Mycobacterium ulcerans environment to Buruli ulcer disease: Progress and challenges

L Dhungel, ME Benbow, HR Jordan - One Health, 2021 - Elsevier
Buruli ulcer (BU), the second most common mycobacterial disease in West Africa, is a
necrotizing skin disease that can lead to high morbidity in affected patients. The disease is …

Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer

BE Hart, LP Hale, S Lee - PLoS neglected tropical diseases, 2015 - journals.plos.org
Buruli ulcer, an emerging tropical disease caused by Mycobacterium ulcerans (MU), is
characterized by disfiguring skin necrosis and high morbidity. Relatively little is understood …