[HTML][HTML] Asprosin exerts pro-inflammatory effects in THP-1 macrophages mediated via the toll-like receptor 4 (TLR4) pathway

K Shabir, S Gharanei, S Orton, V Patel… - International Journal of …, 2022 - mdpi.com
Adipose tissue is a dynamic endocrine organ, secreting a plethora of adipokines which play
a key role in regulating metabolic homeostasis and other physiological processes. An …

[HTML][HTML] Asprosin enhances cytokine production by a co-culture of fully differentiated mature adipocytes and macrophages leading to the exacerbation of the condition …

AI Mazur-Bialy - International Journal of Molecular Sciences, 2023 - mdpi.com
Asprosin, a fasting-induced, glucogenic, and orexigenic adipokine, has gained popularity in
recent years as a potential target in the fight against obesity and its complications. However …

Asprosin attenuates insulin signaling pathway through PKCδ‐activated ER stress and inflammation in skeletal muscle

TW Jung, HC Kim, HU Kim, T Park… - Journal of cellular …, 2019 - Wiley Online Library
It has been reported that asprosin is a novel adipokine which is augmented in mice and
humans with type 2 diabetes (T2DM). Asprosin stimulates hepatic gluconeogenesis under …

Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation

T Lee, S Yun, JH Jeong, TW Jung - Molecular and cellular endocrinology, 2019 - Elsevier
Severe inflammation in the islets is observed in obese patients with type 2 diabetes.
Inflammation in the islets is caused by obesity-induced serum free fatty acids. Asprosin is a …

Asprosin, a novel pleiotropic adipokine implicated in fasting and obesity-related cardio-metabolic disease: Comprehensive review of preclinical and clinical evidence

K Shabir, JE Brown, I Afzal, S Gharanei… - Cytokine & Growth …, 2021 - Elsevier
White adipose tissue is a dynamic endocrine organ that releases an array of adipokines,
which play a key role in regulating metabolic homeostasis and multiple other physiological …

Can the new adipokine asprosin be a metabolic troublemaker for cardiovascular diseases? A state-of-the-art review

Z Zhang, L Zhu, Z Wang, N Hua, S Hu… - Progress in Lipid Research, 2023 - Elsevier
Adipokines play a significant role in cardiometabolic diseases. Asprosin, a newly discovered
adipokine, was first identified as a glucose-raising protein hormone. Asprosin also …

[HTML][HTML] Novel adipokine asprosin modulates browning and adipogenesis in white adipose tissue

Y Miao, H Qin, Y Zhong, K Huang… - Journal of …, 2021 - joe.bioscientifica.com
Obesity is an increasingly serious epidemic worldwide characterized by an increase in the
number and size of adipocytes. Adipose tissue maintains the balance between lipid storage …

Circulating asprosin concentrations are increased in type 2 diabetes mellitus and independently associated with fasting glucose and triglyceride

L Zhang, C Chen, N Zhou, Y Fu, X Cheng - Clinica chimica acta, 2019 - Elsevier
Background Asprosin has been identified as a novel hormone enriched in white adipose
tissue and is pathologically increased in insulin-resistant mice and humans. However …

Circulating levels of asprosin and its association with insulin resistance and renal function in patients with type 2 diabetes mellitus and diabetic nephropathy

G Goodarzi, L Setayesh, R Fadaei, ME Khamseh… - Molecular biology …, 2021 - Springer
Introduction Adipokines play an important role in the development of type 2 diabetes mellitus
(T2DM) and its complications like nephropathy. Asprosin is a newly discovered adipokine …

[HTML][HTML] Asprosin in the paraventricular nucleus induces sympathetic activation and pressor responses via cAMP-dependent ROS production

XL Wang, JX Wang, JL Chen, WY Hao, WZ Xu… - International journal of …, 2022 - mdpi.com
Asprosin is a newly discovered adipokine that is involved in regulating metabolism.
Sympathetic overactivity contributes to the pathogenesis of several cardiovascular diseases …