Maintaining the pulmonary endothelial barrier that prevents the exudation of inflammatory
factors and proteins is the key to the treatment of acute lung injury (ALI). Apelin-13 plays an …

Apelin has been reported to regulate mitochondrial function in myocardial ischemia-
reperfusion injury and cerebral ischemia-reperfusion injury. However, the role of apelin-13 …

The pathophysiology of acute respiratory distress syndrome (ARDS) involves cytokine
storms, alveolar-capillary barrier destruction, and fibrotic progression. Pulmonary interstitial …

Apelin‑36 is able to mediate a range of effects on various diseases, and is upregulated in
lipopolysaccharide (LPS)‑induced acute lung injury (ALI). However, to the best of our …

Apelin is highly expressed in the lungs, especially in the pulmonary vasculature, but the
functional role of apelin under pathological conditions is still undefined. Hypoxic pulmonary …

Background/Aims: Acute lung injury (ALI) is induced by a variety of external and internal
factors and leads to acute progressive respiratory failure. Previous studies have shown that …

Purpose Acute lung injury (ALI) is a life-threatening condition with limited therapeutic
options. Macrophage inflammation plays a key role in the development of ALI. Abnormal …

Fibrotic alterations resulting from abnormal tissue repair after lung injury are responsible for
the high mortality observed after acute respiratory distress syndrome. Therefore, the …

Background: Apelin-13 is an endogenous adipocytokine known for its antioxidant,
antiinflammatory, and antiapoptotic properties. Objective: We aimed to investigate the …

BACKGROUND: Although the mechanisms and pathways mediating ARDS have been
studied extensively, less attention has been given to the mechanisms and pathways that …