Methodological challenges in utilizing mi RNA s as circulating biomarkers

L Moldovan, KE Batte, J Trgovcich… - Journal of cellular …, 2014 - Wiley Online Library
Micro RNA s (mi RNA s) have emerged as important regulators in the post‐transcriptional
control of gene expression. The discovery of their presence not only in tissues but also in …

The biology of circulating micro RNA s in cardiovascular disease

PK Min, SY Chan - European journal of clinical investigation, 2015 - Wiley Online Library
Background Since their first description in mammalian cells, more than 2500 micro RNA
molecules have been predicted or verified within human cells. Recently, extracellular micro …

Circulating microRNAs: novel biomarkers for cardiovascular diseases

J Xu, J Zhao, G Evan, C Xiao, Y Cheng… - Journal of molecular …, 2012 - Springer
MicroRNAs (miRNAs) are a novel class of small, non-coding, single-stranded RNAs that
negatively regulate gene expression via translational inhibition or mRNA degradation …

Standardizing analysis of circulating microRNA: clinical and biological relevance

NH Farina, ME Wood, SD Perrapato… - Journal of cellular …, 2014 - Wiley Online Library
Circulating microRNAs (c‐miRNAs) provide a new dimension as clinical biomarkers for
disease diagnosis, progression, and response to treatment. However, the discovery of …

Circulating microRNAs: Biomarkers of disease

Y Wu, Q Li, R Zhang, X Dai, W Chen, D Xing - Clinica Chimica Acta, 2021 - Elsevier
MicroRNAs are a class of endogenous noncoding single-stranded RNA molecules with
approximately 20–24 nucleotides and are associated with a broad range of biological …

Circulating microRNAs: Association with disease and potential use as biomarkers

G Reid, MB Kirschner, N van Zandwijk - Critical reviews in oncology …, 2011 - Elsevier
The control of gene expression by microRNAs influences many cellular processes and has
been implicated in the control of many (patho) physiological states. Recently, microRNAs …

Cell‐free microRNAs in blood and other body fluids, as cancer biomarkers

B Ortiz‐Quintero - Cell proliferation, 2016 - Wiley Online Library
The discovery of cell‐free micro RNA s (mi RNA s) in serum, plasma and other body fluids
has yielded an invaluable potential source of non‐invasive biomarkers for cancer and other …

[HTML][HTML] Issues and prospects of microRNA-based biomarkers in blood and other body fluids

JR Chevillet, I Lee, HA Briggs, Y He, K Wang - Molecules, 2014 - mdpi.com
Cell-free circulating microRNAs (miRNAs) in the blood are good diagnostic biomarker
candidates for various physiopathological conditions, including cancer, neurodegeneration …

Circulating miRNAs: reflecting or affecting cardiovascular disease?

VPM van Empel, LJ De Windt, PAC Martins - Current hypertension reports, 2012 - Springer
MicroRNAs are a class of small, noncoding RNAs encoded by the metazoan genome that
regulate protein expression. A collection of studies point to vital roles for microRNAs in the …

[HTML][HTML] Serum microRNAs are promising novel biomarkers

S Gilad, E Meiri, Y Yogev, S Benjamin, D Lebanony… - PloS one, 2008 - journals.plos.org
Background Circulating nucleic acids (CNAs) offer unique opportunities for early diagnosis
of clinical conditions. Here we show that microRNAs, a family of small non-coding regulatory …