[PDF][PDF] A heterozygous ZP2 mutation causes zona pellucida defects and female infertility in mouse and human
SL Liu, HY Zuo, BW Zhao, JN Guo, WB Liu, WL Lei… - Iscience, 2023 - cell.com
The zona pellucida (ZP) is an extracellular glycoprotein matrix surrounding mammalian
oocytes. Recently, numerous mutations in genes encoding ZP proteins have been shown to …
oocytes. Recently, numerous mutations in genes encoding ZP proteins have been shown to …
Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility
W Liu, K Li, D Bai, J Yin, Y Tang, F Chi, L Zhang… - Human Genetics, 2017 - Springer
The zona pellucida (ZP) is an extracellular matrix universally surrounding mammalian eggs,
which is essential for oogenesis, fertilization, and pre-implantation embryo development …
which is essential for oogenesis, fertilization, and pre-implantation embryo development …
Heterozygous mutations in ZP1 and ZP3 cause formation disorder of ZP and female infertility in human
The human zona pellucida (ZP) is a highly organized glycoprotein matrix that encircles
oocytes and plays an essential role in successful reproduction. Previous studies have …
oocytes and plays an essential role in successful reproduction. Previous studies have …
Mutations in ZP4 are associated with abnormal zona pellucida and female infertility
X Wei, Y Li, Q Liu, W Liu, X Yan, X Zhu… - Journal of Clinical …, 2022 - jcp.bmj.com
Background The zona pellucida (ZP) of human oocytes plays essential protective roles in
sperm–egg interactions during fertilisation and embryo development. ZP4-null female …
sperm–egg interactions during fertilisation and embryo development. ZP4-null female …
Novel mutations in ZP1, ZP2, and ZP3 cause female infertility due to abnormal zona pellucida formation
Z Zhou, C Ni, L Wu, B Chen, Y Xu, Z Zhang, J Mu, B Li… - Human Genetics, 2019 - Springer
The human zona pellucida (ZP) is an extracellular glycoprotein matrix composed of ZP1,
ZP2, ZP3, and ZP4 surrounding the oocyte, and it plays an important role in sperm–egg …
ZP2, ZP3, and ZP4 surrounding the oocyte, and it plays an important role in sperm–egg …
Identification of zona pellucida defects revealed a novel loss-of-function mutation in ZP2 in humans and rats
J Zeng, Y Sun, J Zhang, X Wu, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Introduction Human zona pellucida (ZP) plays an important role in reproductive process.
Several rare mutations in the encoding genes (ZP1, ZP2, and ZP3) have been demonstrated …
Several rare mutations in the encoding genes (ZP1, ZP2, and ZP3) have been demonstrated …
A novel homozygous variant in ZP2 causes abnormal zona pellucida formation and female infertility
Y Sun, Y Zeng, H Chen, Z Zhou, J Fu, Q Sang… - Journal of Assisted …, 2021 - Springer
Purpose We aimed to identify pathogenic variants in two infertile sisters in a family with a
thin zona pellucida (ZP) phenotype. Methods Whole-exome sequencing was performed in …
thin zona pellucida (ZP) phenotype. Methods Whole-exome sequencing was performed in …
Novel Heterozygous Mutations in ZP2 Cause Abnormal Zona Pellucida and Female Infertility
M Hou, L Zhu, J Jiang, Z Liu, Z Li, W Jia, J Hu… - Reproductive …, 2022 - Springer
Zona pellucida (ZP) which is an extracellular matrix consisting of ZP1, ZP2, ZP3, and ZP4
plays a vital role in oocyte maturity, early embryonic development, and fertilization process …
plays a vital role in oocyte maturity, early embryonic development, and fertilization process …
Zp4 is completely dispensable for fertility in female rats
MH Zeng, Y Wang, HL Huang, RP Quan… - Biology of …, 2021 - academic.oup.com
Zona pellucida (ZP), which is composed of at most four extracellular glycoproteins (ZP1,
ZP2, ZP3, and ZP4) in mammals, shelters the oocytes and is vital in female fertility. Several …
ZP2, ZP3, and ZP4) in mammals, shelters the oocytes and is vital in female fertility. Several …
Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in rats
C Lv, HL Huang, DJ Yi, TL Peng, HJ Tan… - Biology of …, 2021 - academic.oup.com
The zona pellucida (ZP) plays vital roles in reproductive processes including oogenesis,
fertilization, and preimplantation development. Both human and rat ZP consist of four …
fertilization, and preimplantation development. Both human and rat ZP consist of four …