Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions

N Rapoport, KH Nam, R Gupta, Z Gao, P Mohan… - Journal of Controlled …, 2011 - Elsevier
Perfluorocarbon nanoemulsions can deliver lipophilic therapeutic agents to solid tumors and
simultaneously provide for monitoring nanocarrier biodistribution via ultrasonography and/or …

Synthesis of stable multifunctional perfluorocarbon nanoemulsions for cancer therapy and imaging

DA Fernandes, DD Fernandes, Y Li, Y Wang, Z Zhang… - Langmuir, 2016 - ACS Publications
Nanotechnology provides a promising platform for drug-delivery in medicine.
Nanostructured materials can be designed with desired superparamagnetic or fluorescent …

Drug-loaded nano/microbubbles for combining ultrasonography and targeted chemotherapy

Z Gao, AM Kennedy, DA Christensen, NY Rapoport - Ultrasonics, 2008 - Elsevier
A new class of multifunctional nanoparticles that combine properties of polymeric drug
carriers, ultrasound imaging contrast agents, and enhancers of ultrasound-mediated drug …

Perfluorocarbon nanoemulsions for quantitative molecular imaging and targeted therapeutics

MM Kaneda, S Caruthers, GM Lanza… - Annals of biomedical …, 2009 - Springer
A broad array of nanomaterials is available for use as contrast agents for molecular imaging
and drug delivery. Due to the lack of endogenous background signal in vivo and the high …

Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy

N Rapoport, Z Gao, A Kennedy - Journal of the National Cancer …, 2007 - academic.oup.com
Background Drug delivery in polymeric micelles combined with tumor irradiation by
ultrasound results in effective drug targeting, but this technique requires prior tumor imaging …

Multicore Liquid Perfluorocarbon‐Loaded Multimodal Nanoparticles for Stable Ultrasound and 19F MRI Applied to In Vivo Cell Tracking

O Koshkina, G Lajoinie… - Advanced functional …, 2019 - Wiley Online Library
Ultrasound is the most commonly used clinical imaging modality. However, in applications
requiring cell‐labeling, the large size and short active lifetime of ultrasound contrast agents …

Improving performance of nanoscale ultrasound contrast agents using N, N-diethylacrylamide stabilization

RH Perera, H Wu, P Peiris, C Hernandez… - … , Biology and Medicine, 2017 - Elsevier
The design of nanoscale yet highly echogenic agents for imaging outside of the vasculature
and for ultrasound-mediated drug delivery remains a formidable challenge. We have …

Low-intensity focused ultrasound (LIFU)-activated nanodroplets as a theranostic agent for noninvasive cancer molecular imaging and drug delivery

J Liu, F Xu, J Huang, J Xu, Y Liu, Y Yao, M Ao… - Biomaterials …, 2018 - pubs.rsc.org
Theranostics is a new trend in the tumor research field, which involves the integration of
diagnostic and therapeutic functions using imageable nanoparticles coupled with …

The performance of PEGylated nanocapsules of perfluorooctyl bromide as an ultrasound contrast agent

R Díaz-López, N Tsapis, M Santin, SL Bridal, V Nicolas… - Biomaterials, 2010 - Elsevier
The surface of polymeric nanocapsules used as ultrasound contrast agents (UCAs) was
modified with PEGylated phospholipids in order to escape recognition and clearance by the …

Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles

NY Rapoport, AM Kennedy, JE Shea, CL Scaife… - Journal of Controlled …, 2009 - Elsevier
The paper reports the results of nanotherapy of ovarian, breast, and pancreatic cancerous
tumors by paclitaxel-loaded nanoemulsions that convert into microbubbles locally in tumor …